PLA0199
Anti-Vimentin Antibody
from rabbit
Synonym(s):
CTRCT30, HEL113, epididymis luminal protein 113
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Species reactivity:
mouse, human
Technique(s):
immunohistochemistry: 1:200-1:1,000, western blot: 1:2,000- 1:10,000
Application:
IHC, WB
Citations:
6
Product Name
Rabbit anti-Vimentin Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.
biological source
rabbit
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
species reactivity
mouse, human
technique(s)
immunohistochemistry: 1:200-1:1,000, western blot: 1:2,000- 1:10,000
accession no.
NP_003371.2
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
rabbit ... Vimentin(7431)
General description
Vimentin is a specific type III intermediate filament (IF) protein. It is abundantly expressed in mesenchymal cells. The gene encoding this protein is localized on human chromosome 10p13.
Immunogen
The epitope recognized by PLA0199 maps to a region between residue 416 and 466 of human vimentin using the numbering given in entry NP_003371.2 (GeneID 7431).
Biochem/physiol Actions
Vimentin helps to preserve the structure of cell and stability of tissue in mesenchymal cells. It is involved in tumorigenesis, EMT (epithelial mesenchymal transition) and the metastatic spread of cancer. It also controls infectious internalization of human papillomavirus 16 pseudovirions.
Physical form
Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide
Other Notes
Vimentin is an intermediate filament expressed mainly in mesenchymal tissue and in primitive (undifferentiated) non-mesenchymal cells. It is a Class III cytoplasmic filament that forms a dense cytoskeletal network that extends from the nucleus to the plasma membrane. Vimentin reorganization during mitosis is likely regulated via its multiple phosphorylation sites. Vimentin expression is also found in mesoderm derived epithelia. Immunohistochemistry (IHC) with anti-vimentin antibodies is often used to identify neoplasms of mesenchymal or mesodermal origin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Vimentin modulates infectious internalisation of HPV16 pseudovirions
Schafer G, et al.
Journal of Virology, JVI-00307 (2017)
Mohammad Mehedi Hasan et al.
International journal of molecular sciences, 21(15) (2020-08-01)
While follicular fluid (FF) is well known to provide an optimal environment for oogenesis, its functional roles following its release into the oviduct during ovulation are currently elusive. We hypothesized that FF and FF-derived extracellular vesicles (EVs) may be conveyors
Viscoelastic properties of vimentin compared with other filamentous biopolymer networks.
Janmey PA, et al.
The Journal of Cell Biology, 113(1), 155-160 (1991)
Qurat Ul Ain Reshi et al.
Journal of cell communication and signaling, 14(4), 439-451 (2020-09-04)
The capability of spermatozoa to directly influence maternal gene expression is already established. Indeed, some of the changes induced by spermatozoa may have a direct functional importance in the pre-conceptional period. Although the mechanisms underlying these sperm-maternal interactions are not
Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial?mesenchymal transition-related proteins.
Liu P F, et al.
PLoS ONE, 12(6), e0178581-e0178581 (2017)
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