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PLA0203

Sigma-Aldrich

Rabbit anti-cAbl Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):
c-ABL1, receptor tyrosine kinase, JTK7, proto-oncogene c-Abl, non-receptor tyrosine kinase, bcr/c-abl oncogene protein, c-abl oncogene 1, v-abl Abelson murine leukemia viral oncogene homolog 1, proto-oncogene tyrosine-protein kinase ABL1, ABL, p150, v-abl, c-ABL, bcr/abl, Abelson tyrosine-protein kinase 1, Abelson murine leukemia viral oncogene homolog 1
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

application(s)

immunofluorescence: 1:100-1:1,000
immunohistochemistry: 1:100- 1:1,000
immunoprecipitation (IP): 2- 5 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_005148.2

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... cAbl(25)

Immunogen

The epitope recognized by PLA0203 maps to a region between residue 550 and 600 of human v-abl Abelson murine leukemia viral oncogene homolog 1 using the numbering given in entry NP_005148.2 (GeneID 25).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

c-Abl is the human cellular homolog of a the v-Abl viral oncogene. v-Abl was originally discovered as a mouse cell-derived sequence in the genome of the Abelson murine leukemia virus (A-MuLV), a transforming retrovirus isolated by the laboratory of Dr. H.T. Abelson. c-Abl is a tyrosine kinase from the Src-family of tyrosine kinases that localizes to both the cytoplasm and nucleus. It bears an SH2 (src-homology 2) and SH3 (src-homology 3) domain responsible for mediating c-Abl protein-protein interactions. c-Abl is implicated to play a role in multiple cellular processes such as cell cycle checkpoint signaling, apoptosis, cell differentiation, cell adhesion, and transcriptional regulation. Chromosomal translocations involving the c-Abl gene are associated with human leukemias.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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