Rabbit anti-NF-kappaB1 Antibody, Affinity Purified

The epitope recognized by PLA0214 maps to a region between residue 1 and 50 of human nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) using the numbering given in entry AAF35232.1 (GeneID 4790).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

The NFKB1 gene encodes a 105 kDa protein that can undergo co-translational processing to also yield a 50 kDa protein. The 50 kDa protein is also known as NF-kappa B1/p50 and is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. The 105 kDa product is also known as p105 or I kappa B gamma. p105/I kappa B gamma has been shown to function as an inhibitor protein that interacts with NF-kappa B and inhibit its DNA binding activity. p105/I kappa B gamma is a member of the I kappa B family of proteins which includes I kappa B-beta, I kappa B-delta/NF-kappa B2/p100, I kappa B-gamma/NF-kappa B1/p105, I kappa B-epsilon, I kappa B-zeta, and Bcl3. The classical description of the NF-kappa B transcription factor is a transcription factor that reprograms gene expression of the immune system in response to injury, infection, and stress.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.