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Merck
CN

PLA0217

Sigma-Aldrich

Rabbit anti-c-Rel Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

I-Rel, avian reticuloendotheliosis, c-Rel, oncogene REL, v-rel avian reticuloendotheliosis viral oncogene homolog

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
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biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

species reactivity

human

technique(s)

immunoprecipitation (IP): 2- 5 μg/mg

accession no.

NP_002899.1

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... c-Rel(5966)

Immunogen

The epitope recognized by PLA0217 maps to a region between residue 325 and 375 of human reticuloendotheliosis viral oncogene homolog using the numbering given in entry NP_002899.1 (GeneID 5966).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

c-Rel is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. Each Rel member bears a characteristic 300 amino acid N-terminal Rel homology domain (RHD). c-Rel was originally identified as the cellular version of the v-Rel oncogene derived from the avian reticuloendotheliosis retrovirus.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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The pathological hallmarks of Parkinson's disease (PD) are the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and the presence of overactivated glial cells and neuroinflammation. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) c-Rel
Yong-Joon Choi et al.
Scientific reports, 9(1), 10599-10599 (2019-07-25)
The transcription factor HIF-1 induces the expression of genes that are essential for cell survival and oxygen homeostasis in hypoxic conditions. The prolyl isomerase Pin1 plays a role in the regulation of HIF-1α. However, the mechanism by which Pin1 controls HIF-1α
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Respiratory syncytial virus (RSV) is a highly prevalent infectious agent that causes severe respiratory tract illnesses in infants and children worldwide. Children who have suffered severe RSV infections during infancy are prone to develop recurrent episodes of wheezing and asthma
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The complex signaling dynamics of transcription factors can encode both qualitative and quantitative information about the extracellular environment, which increases the information transfer capacity and potentially supports accurate cellular decision-making. An important question is how these signaling dynamics patterns are
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Journal of cellular physiology, 235(2), 1103-1119 (2019-06-27)
Osteosarcoma (OS) is a rare, insidious tumor of mesenchymal origin that most often affects children, adolescents, and young adults. While the primary tumor can be controlled with chemotherapy and surgery, it is the lung metastases that are eventually fatal. Multiple

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