PLA0222
Rabbit anti-Notch1 Antibody, Affinity Purified
Powered by Bethyl Laboratories, Inc.
Synonym(s):
AOS5, AOVD1, Notch (Drosophila) homolog 1 (translocation-associated), Notch 1, Notch homolog 1, TAN1, hN1, translocation-associated, translocation-associated (Drosophila), translocation-associated notch protein TAN-1
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
biological source
rabbit
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
species reactivity
human
technique(s)
immunoprecipitation (IP): 2-5 μg/mg
accession no.
NP_060087.3
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Gene Information
rabbit ... Notch1(4851)
Immunogen
The epitope recognized by PLA0222 maps to a region between residue 2400 and 2450 of human Notch ortholog 1, translocation-associated using the numbering given in entry NP_060087.3 (GeneID 4851).
Application
Product PLA0222, Powered by Bethyl Laboratories, has been pre-qualified for use in proximity ligation assay (PLA®). PLA® technology enables visualization of protein interactions in fixed cells and tissue samples while under endogenous protein expression levels.
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Other Notes
Notch1 is the human homolog of the D. melanogaster Notch gene first reported as the gene responsible for the presence of notches in the wingblades of a specific strain of flies. The Notch protein is a transmembrane receptor that mediates juxtacrine signals between adjacent cells. Mammalian Notch1 ligands include Delta-like and Jagged. Upon ligand binding, Notch1 undergoes two proteolytic cleavage events that result in the release of the intracellular Notch1 domain and its translocation to the nucleus where it can participate in gene transactivation. Notch 1 signals mediate cellular fate, differentiation, and development.
Legal Information
PLA is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Heather R Hensler et al.
Virus research, 190, 97-103 (2014-07-16)
We have previously shown that human herpesvirus 8 (HHV-8) uses DC-SIGN as an entry receptor for dendritic cells, macrophages and B cells. The viral attachment protein for DC-SIGN is unknown. HHV-8 virions contain five conserved herpesvirus glycoproteins, a single unique
Aušra Sasnauskienė et al.
Medicina (Kaunas, Lithuania), 50(1), 14-18 (2014-07-26)
Notch signaling is a conserved developmental pathway, which plays an important role in the regulation of cell proliferation, differentiation and death. Deregulation of Notch pathway has been connected with the carcinogenesis in a variety of cancers. The aim of this
Laura Asnaghi et al.
PloS one, 9(8), e105372-e105372 (2014-08-29)
The transcriptional response promoted by hypoxia-inducible factors has been associated with metastatic spread of uveal melanoma. We found expression of hypoxia-inducible factor 1α (HIF-1α) protein in well-vascularized tumor regions as well as in four cell lines grown in normoxia, thus
R Schwarzer et al.
Blood cancer journal, 4, e217-e217 (2014-06-14)
Despite evidence that deregulated Notch signalling is a master regulator of multiple myeloma (MM) pathogenesis, its contribution to myeloma bone disease remains to be resolved. Notch promotes survival of human MM cells and triggers human osteoclast activity in vitro. Here
Shenxu Wang et al.
Experimental lung research, 40(8), 404-414 (2014-08-26)
To investigate the effect of cisplatin on the growth and metastasis abilities of lung cancer stem cells (CSCs) via molecular imaging. The expression changes of lung CSCs cell marker in A549-Luc-C8 human non-small-cell lung cancer (NSCLC) cell line with or
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