PLA0234
Rabbit anti-BCR Antibody, Affinity Purified
Powered by Bethyl Laboratories, Inc.
Synonym(s):
ALL, BCR/FGFR1 chimera protein, BCR1, CML, D22S11, D22S662, FGFR1/BCR chimera protein, PHL, breakpoint cluster region, renal carcinoma antigen NY-REN-26
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Quality Level
biological source
rabbit
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
species reactivity
human
technique(s)
flow cytometry: 0.5 μg, immunofluorescence: 1:500- 1:2,000, immunoprecipitation (IP): 10 μg/mg, western blot: 1:2,000- 1:10,000
accession no.
NP_004318.3
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
Gene Information
rabbit ... BCR(613)
Immunogen
The epitope recognized by PLA0234 maps to a region between residue 1221 and 1271 of human breakpoint cluster region using the numbering given in entry NP_004318.3 (GeneID 613).
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Other Notes
BCR (breakpoint cluster region) was identified as part of a fusion protein that results from a reciprocal translocation with the ABL gene between chromosomes 22 and 9. The BCR-ABL fusion is the cause of chronic myeloid leukemia (CML). The BCR protein contains a C2 domain, a DBL-homology domain, a PH domain, and a Rho-GAP domain and functions as a GTPase-activating protein for RAC1 and CDC42.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
低风险生物材料
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Wan Ru Lee et al.
PloS one, 10(4), e0124494-e0124494 (2015-04-18)
Scavenger receptor class B, type I (SR-BI) and its adaptor protein PDZK1 mediate responses to HDL cholesterol in endothelium. Whether the receptor-adaptor protein tandem serves functions in other vascular cell types is unknown. The current work determined the roles of