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All Photos(2)

PLA0263

Sigma-Aldrich

Rabbit anti-Ku70 Antibody, Affinity Purified

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Synonym(s):
TLAA, KU70, ML8, CTC box-binding factor 75 kDa subunit, ATP-dependent DNA helicase 2 subunit 1, X-ray repair complementing defective repair in Chinese hamster cells 6, Ku autoantigen p70 subunit, D22S731, ATP-dependent DNA helicase II, thyroid autoantigen 70kDa (Ku antigen), 5′-dRP lyase Ku70, Thyroid-lupus autoantigen, CTC75, Ku autoantigen, D22S671, thyroid autoantigen 70kD (Ku antigen), thyroid-lupus autoantigen p70, CTC box binding factor 75 kDa subunit, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase II 70 kDa subunit, G22P1, 70 kDa subunit, 5′-deoxyribose-5-phosphate lyase Ku70, 70kDa, CTCBF, lupus Ku autoantigen protein p70, DNA repair protein XRCC6
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

technique(s)

immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_001460.1

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... Ku70(2547)

Immunogen

The epitope recognized by PLA0263 maps to a region between residue 500 and 550 of human Lupus Ku autoantigen protein p70 using the numbering given in entry NP_001460.1 (GeneID 2547).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

Ku70 is the 70 kDa subunit of the lupus Ku autoantigen. The lupus Ku autoantigen was identified in individuals with systemic lupus erythematosus (SLE) and related disorders. The Ku antigen is a heterodimer of Ku70 and Ku80. The Ku70/Ku80 complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P12956].

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Haiwen Li et al.
Oncology reports, 32(6), 2596-2604 (2014-10-22)
Nasopharyngeal carcinoma (NPC) is a leading cause of cancer-related mortality. Radiotherapy is one of the primary modalities for NPC treatment. However, in patients in the late stages of the disease, the local control rate and overall survival rate remain low.
Eui Young So et al.
Cancer biology & therapy, 15(7), 906-910 (2014-04-24)
The bone marrow (BM) is one of the organs that is sensitive to acute exposure of ionizing radiation (IR); however, the mechanism of its high sensitivity to IR remains to be elucidated. BM is differentiated into dendritic cells (DC) with

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