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PLA0304

Sigma-Aldrich

Goat anti-HIF1-alpha Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):
hypoxia-inducible factor1alpha, member of PAS superfamily 1, alpha subunit (basic helix-loop-helix transcription factor), HIF-1A, ARNT interacting protein, bHLHe78, PASD8, PAS domain-containing protein 8, ARNT-interacting protein, HIF-1-alpha, HIF1, class E basic helix-loop-helix protein 78, HIF1-ALPHA, HIF-1alpha, member of PAS protein 1, basic-helix-loop-helix-PAS protein MOP1, hypoxia inducible factor 1, hypoxia-inducible factor 1, MOP1, hypoxia-inducible factor 1 alpha isoform I.3
NACRES:
NA.41

Quality Level

biological source

goat

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

concentration

1 mg/mL

application(s)

immunoprecipitation (IP): 2- 10 μg/mg

accession no.

NP_001521.1

shipped in

wet ice

storage temp.

2-8°C

Gene Information

Immunogen

The epitope recognized by PLA0304 maps to a region between residue 776 and 826 of human Hypoxia-Inducible Factor 1, Alpha Subunit using the numbering given in entry NP_001521.1 (GeneID 3091).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

Hypoxia-inducible factor-1 (HIF1) is a basic helix-loop-helix (bHLH)-PER-ARNT-sim (PAS) transcription factor that plays a role in the cellular response to hypoxia. HIF1 is a heterodimer of an HIF1-alpha and HIF1-beta subunit. During normoxia, HIF-1alpha is regulated by ubiquitination and interaction with the von-Hippel-Lindau tumor suppressor protein (pVHL).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Magdalena H Menhofer et al.
Cardiovascular research, 104(2), 303-314 (2014-09-23)
Inhibiting angiogenesis is a major approach in tumour therapy. To combat angiogenesis, the tubulin cytoskeleton has emerged as an interesting target in many pre- and clinical studies. Contrarily, the actin cytoskeleton has been largely neglected as a potential drug target
Junhua Mao et al.
American journal of physiology. Renal physiology, 307(9), F1023-F1032 (2014-07-06)
Podocytes play a key role in the formation of cellular crescents in experimental and human diseases. However, the underlying mechanisms for podocytes in promoting crescent formation need further investigation. Here, we demonstrated that mammalian target of rapamycin complex 1 (mTORC1)

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