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Merck
CN

PZ0036

Rucaparib camsylate

≥98% (HPLC)

Synonym(s):

8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one camsylate

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About This Item

Empirical Formula (Hill Notation):
C19H18FN3O · C10H16O4S
CAS Number:
1859053-21-6
Molecular Weight:
555.66
UNSPSC Code:
12352202
NACRES:
NA.77

Key Documents

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Product Name

Rucaparib camsylate, ≥98% (HPLC)

InChI

1S/C19H18FN3O.C10H16O4S/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15;1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);7H,3-6H2,1-2H3,(H,12,13,14)/t;7-,10-/m.1/s1

InChI key

INBJJAFXHQQSRW-STOWLHSFSA-N

SMILES string

FC1=CC(C(NCC2)=O)=C3C2=C(C4=CC=C(CNC)C=C4)NC3=C1.CC5(C)[C@@H]6CC[C@@]5(CS(O)(=O)=O)C(C6)=O

assay

≥98% (HPLC)

form

powder

color

pale yellow

solubility

DMSO: 2 mg/mL, clear

shipped in

dry ice

storage temp.

−20°C

Biochem/physiol Actions

PARP Inhibitor; anticancer agent
Rucaparib is an inhibitor of the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It has been found to have anticancer activity in a number of cancers and has been approved for treatment of previously treated, BRCA-mutant ovarian cancer.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000359590
0000359590
0000182111
0000182111
0000131396

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Yaroslava Karpova et al.
Biochemical pharmacology, 167, 149-162 (2019-03-19)
In our previous studies of the molecular mechanisms of poly(ADP-ribose) polymerase 1 (PARP-1)-mediated transcriptional regulation we identified a novel class of PARP-1 inhibitors targeting the histone-dependent route of PARP-1 activation. Because histone-dependent activation is unique to PARP-1, non-NAD-like PARP-1 inhibitors

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