PZ0332
ISOX-INACT
≥98% (HPLC)
Synonym(s):
4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-methoxyphenethyl)-4,6-dimethyl-1Hbenzo[d]imidazol-1-yl)ethyl)morpholine
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About This Item
Empirical Formula (Hill Notation):
C29H36N4O3
CAS Number:
Molecular Weight:
488.62
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
SMILES string
CC1=NOC(C)=C1C2=C(C)C(N=C(CCC3=CC=C(OC)C=C3)N4CCN5CCOCC5)=C4C=C2C
InChI
1S/C29H36N4O3/c1-19-18-25-29(20(2)27(19)28-21(3)31-36-22(28)4)30-26(11-8-23-6-9-24(34-5)10-7-23)33(25)13-12-32-14-16-35-17-15-32/h6-7,9-10,18H,8,11-17H2,1-5H3
InChI key
FTOHXUPHICJSCR-UHFFFAOYSA-N
Biochem/physiol Actions
CBP BRD (CREB binding protein bromodomain) inhibition serves as an effective therapeutic target for Parkinson′s disease. The inhibition is followed by negative regulation of a number of macrophage inflammatory genes. It also downregulates G-protein signaling 4 mRNA.
ISOX-INACT is an inactive control probe for the highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) PF-CBP1.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Eugene L Piatnitski Chekler et al.
Chemistry & biology, 22(12), 1588-1596 (2015-12-17)
Bromodomains are involved in transcriptional regulation through the recognition of acetyl lysine modifications on diverse proteins. Selective pharmacological modulators of bromodomains are lacking, although the largely hydrophobic nature of the pocket makes these modules attractive targets for small-molecule inhibitors. This
Global Trade Item Number
| SKU | GTIN |
|---|---|
| PZ0332-25MG | 04061832824321 |
| PZ0332-5MG | 04061832824338 |