PZ0356
PF-06291874
≥98% (HPLC)
Synonym(s):
N-[4-[(1S)-1-[3,5-Dimethyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenoxy]butyl]benzoyl]--alanine
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C26H28F3N3O4
CAS Number:
Molecular Weight:
503.51
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
SMILES string
FC(F)(F)c1c[n](nc1)c2c(cc(cc2C)O[C@@H](CCC)c3ccc(cc3)C(=O)NCCC(=O)O)C
InChI key
IBDYYOQKQCCSDP-QFIPXVFZSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
room temp
Quality Level
Biochem/physiol Actions
PF-06291874 is an orally active, potent and selective glucagon receptor antagonist. PF-06291874 exhibits a robust glucose reductions in subjects with type 2 diabetes mellitus.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Arthur Bergman et al.
Diabetes research and clinical practice, 126, 95-104 (2017-02-27)
The glucagon receptor antagonist PF-06291874 has demonstrated robust glucose reductions in subjects with type 2 diabetes mellitus (T2DM) on background metformin. This study assessed the pharmacokinetics, pharmacodynamics, safety, and tolerability of PF-06291874 administered as monotherapy in subjects with T2DM. After
Esther C Y Lee et al.
Bioorganic & medicinal chemistry letters, 24(3), 839-844 (2014-01-15)
Identification of orally active, small molecule antagonists of the glucagon receptor represents a novel treatment paradigm for the management of type 2 diabetes mellitus. The present work discloses novel glucagon receptor antagonists, identified via conformational constraint of current existing literature
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service