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Merck
CN

PZ0364

DIBA-1

≥97% (NMR)

Synonym(s):

2,2′-Disulfanediylbis(N-(4-sulfamoylphenyl)benzamide, 2,2′-Dithiobis[N-[4-(aminosulfonyl)phenyl]benzamide], NSC 654077, PD022551

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About This Item

Empirical Formula (Hill Notation):
C26H22N4O6S4
CAS Number:
171744-39-1
Molecular Weight:
614.74
UNSPSC Code:
51111800
NACRES:
NA.77

Key Documents

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SMILES string

[S](=O)(=O)(N)c1ccc(cc1)NC(=O)c2c(cccc2)SSc3c(cccc3)C(=O)Nc4ccc(cc4)[S](=O)(=O)N

InChI

1S/C26H22N4O6S4/c27-39(33,34)19-13-9-17(10-14-19)29-25(31)21-5-1-3-7-23(21)37-38-24-8-4-2-6-22(24)26(32)30-18-11-15-20(16-12-18)40(28,35)36/h1-16H,(H,29,31)(H,30,32)(H2,27,33,34)(H2,28,35,36)

InChI key

FVGJPHFQQMQGFQ-UHFFFAOYSA-N

assay

≥97% (NMR)

form

powder

color

white to light brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

DIBA-1 (2,2′-dithiobisbenzamide-1) is a disulfide that interacts with zinc fingers as a zinc ejector. It has been shown to interact with many zinc finger containing proteins, including HIV-1 nucleocapsid and the estrogen receptor. DIBA-1 has been studied as a candidate for the treatment of AIDS and also breast cancer. In one study DIBA restored tamoxifen sensitivity in resistant breast cancer.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000027074
0000027076
0000019308

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Li Hua Wang et al.
Cancer cell, 10(6), 487-499 (2006-12-13)
A serious obstacle to successful treatment of estrogen receptor (ER)-positive human breast cancer is cell resistance to tamoxifen (TAM) therapy. Here we show that the electrophile disulfide benzamide (DIBA), an ER zinc finger inhibitor, blocks ligand-dependent and -independent cell growth
Kevin Carayon et al.
Nucleic acids research, 38(11), 3692-3708 (2010-02-19)
HIV-1 integrase catalyzes the insertion of the viral genome into chromosomal DNA. We characterized the structural determinants of the 3'-processing reaction specificity--the first reaction of the integration process--at the DNA-binding level. We found that the integrase N-terminal domain, containing a
M Huang et al.
Journal of medicinal chemistry, 41(9), 1371-1381 (1998-05-23)
Agents that target the two highly conserved Zn fingers of the human immunodeficiency virus (HIV) nucleocapsid p7 (NCp7) protein are under development as antivirals. These agents covalently modify Zn-coordinating cysteine thiolates of the fingers, causing Zn ejection, loss of native

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