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About This Item
Empirical Formula (Hill Notation):
C24H29N7O2
CAS Number:
Molecular Weight:
447.53
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Product Name
Palbociclib, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
0.1 M HCl: 2 mg/mL, clear
storage temp.
room temp
SMILES string
CC(C1=C(N2C3CCCC3)N=C(NC4=CC=C(N5CCNCC5)C=N4)N=C1)=C(C(C)=O)C2=O
InChI
1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
InChI key
AHJRHEGDXFFMBM-UHFFFAOYSA-N
Biochem/physiol Actions
PF-00080665 (Palbociclib; PD 0332991) is an orally active and highly specific inhibitor against cyclin-dependent kinase 4 & 6 (IC50 = 9, 11, 15 nM, respectively, using CDK4/cycD3, CDK4/cycD1, CDK6/cycD2; IC50 >10 μM against 36 other kinases) that potently suppresses Cdk4/6-dependent cellular Rb phosphorylation (IC50 = 66 nM/pSer780 & 63 nM/pSer795; MDA-MB-435). PF-00080665 exhibits selective antiproliferation activity against Rb-positive human breast/colon/lung/leukemia cancer cultures (IC50 = 40-400 nM; IC50 >3 μM/Rb-negative MDA-MB-468 & H2009) and displays in vivo efficacy against various advanced stage human tumor xenografts in mice (12.5-150 mg/kg/day p.o.).
Preparation Note
This chemical can be stored in solution at -80°C for 6 months and at -20°C for 1 month (protect from light).
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Muta. 2 - Repr. 2 - STOT RE 2 Oral
target_organs
Bone marrow,male reproductive organs
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| PZ0383-25MG | 04061838691163 |
| PZ0383-5MG | 04061838691170 |

