PZ0385
PFE-360
≥98% (HPLC)
Synonym(s):
1-Methyl-4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-1H-pyrrole-2-carbonitrile, PF-06685360, PFE360
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About This Item
Empirical Formula (Hill Notation):
C16H16N6O
CAS Number:
Molecular Weight:
308.34
UNSPSC Code:
12352202
InChI key
IYQTYHISVSPMSU-UHFFFAOYSA-N
SMILES string
CN1C(C#N)=CC(C2=CNC3=C2C(N4CCOCC4)=NC=N3)=C1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
room temp
Biochem/physiol Actions
LRRK2 modulator
PFE-360 (PF-06685360) is a poten and elective inhibitor of LRRK2 kinase.
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
Storage Class
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Andrew B West
Experimental neurology, 298(Pt B), 236-245 (2017-08-03)
In the translation of discoveries from the laboratory to the clinic, the track record in developing disease-modifying therapies in neurodegenerative disease is poor. A carefully designed development pipeline built from discoveries in both pre-clinical models and patient populations is necessary
Kenneth Thirstrup et al.
Scientific reports, 7(1), 10300-10300 (2017-09-02)
Genetic variation in the leucine-rich repeat kinase 2 (LRRK2) gene is associated with risk of familial and sporadic Parkinson's disease (PD). To support clinical development of LRRK2 inhibitors as disease-modifying treatment in PD biomarkers for kinase activity, target engagement and
Michael Aagaard Andersen et al.
Toxicology, 395, 15-22 (2018-01-09)
Parkinson's disease (PD) is a progressive neurodegenerative disorder for which there is no existing therapeutic approach to delay or stop progression. Genetic, biochemical and pre-clinical studies have provided evidence that leucine-rich-repeat-kinase-2 (LRRK2) kinase is involved in the pathogenesis of PD
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