R0408
Ro 60-0175
≥99% (HPLC)
Synonym(s):
(aS)-6-Chloro-5-fluoro-a-methyl-1H-indole-1-ethanamine monofumarate
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About This Item
Empirical Formula (Hill Notation):
C11H12ClFN2 ·C4H4O4
Molecular Weight:
342.75
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥99% (HPLC)
form
solid
solubility
deionized water: 10 mg/mL
storage temp.
2-8°C
SMILES string
OC(=O)\C=C\C(O)=O.C[C@H](N)Cn1ccc2cc(F)c(Cl)cc12
InChI
1S/C11H12ClFN2.C4H4O4/c1-7(14)6-15-3-2-8-4-10(13)9(12)5-11(8)15;5-3(6)1-2-4(7)8/h2-5,7H,6,14H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t7-;/m0./s1
InChI key
CEPHEXXZGQBXGT-XZTIXWOLSA-N
Biochem/physiol Actions
Ro 60-0175 is a potent, selective 5-HT2 receptor agonist.
Ro 60-0175 was originally reported to be a potent, selective 5-HT2C receptor agonist (with pKi values of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). That assignment has been questioned, however, supported by evidence from coadministration of Ro 60-0175 and SB 242084, a selective 5-HT2C antagonist.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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