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Merck
CN

R0529

Ro 90-7501

≥98% (HPLC)

Synonym(s):

2′-(4-Aminophenyl)-[2,5′-bi-1H-benzimidazol]-5-amine

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About This Item

Empirical Formula (Hill Notation):
C20H16N6
CAS Number:
293762-45-5
Molecular Weight:
340.38
UNSPSC Code:
12352200
PubChem Substance ID:
24724587
MDL number:
MFCD00367977

Key Documents

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InChI

1S/C20H16N6/c21-13-4-1-11(2-5-13)19-23-15-7-3-12(9-17(15)25-19)20-24-16-8-6-14(22)10-18(16)26-20/h1-10H,21-22H2,(H,23,25)(H,24,26)

SMILES string

Nc1ccc(cc1)-c2nc3ccc(cc3[nH]2)-c4nc5ccc(N)cc5[nH]4

InChI key

PAGZCEHLFCJSPV-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

brown

solubility

DMSO: ~20 mg/mL, H2O: insoluble

originator

Roche

Biochem/physiol Actions

Inhibitor of Aß42 fibril formation

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
035K4715

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B Bohrmann et al.
Journal of structural biology, 130(2-3), 232-246 (2000-08-15)
Assemblyof the amyloid-beta peptide (Abeta) into fibrils and its deposition in distinct brain areas is considered responsible for the pathogenesis of Alzheimer's disease (AD). Thus, inhibition of fibril assembly is a potential strategy for therapeutic intervention. Electron cryomicroscopy was used
Katelyn E Zulauf et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(47), 29839-29850 (2020-11-11)
Carbapenem-resistant Enterobacteriaceae (CRE) are multidrug-resistant pathogens for which new treatments are desperately needed. Carbapenemases and other types of antibiotic resistance genes are carried almost exclusively on large, low-copy-number plasmids (pCRE). Accordingly, small molecules that efficiently evict pCRE plasmids should restore
Christopher A Ross et al.
Nature medicine, 10 Suppl, S10-S17 (2004-07-24)
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are increasingly being realized to have common cellular and molecular mechanisms including protein aggregation and inclusion body formation. The aggregates
Zhihao Li et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 148, 21-29 (2020-04-21)
Radiotherapy plays a crucial role in the treatment of cervical cancer, but existing radiosensitizers have limited efficacy in clinical applications. The aims of this study were to establish and verify an efficient method for identifying new radiosensitizers, to use this
Sally Park et al.
Small GTPases, 12(2), 147-160 (2019-10-12)
Rho proteins are signalling molecules that control cellular dynamics, movement and morphological changes. They are activated by Rho guanine-nucleotide exchange factors (Rho GEFs) that transduce upstream signals into Rho-mediated activation of downstream processes. Fgd5 is a Rho GEF involved in
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