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Merck
CN

R106

Sigma-Aldrich

Ro 16-6491 hydrochloride

solid

Synonym(s):

N-(2-Aminoethyl)-4-chlorobenzamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C9H11ClN2O · HCl
CAS Number:
94319-79-6
Molecular Weight:
235.11
MDL number:
MFCD00078595
UNSPSC Code:
12352200
PubChem Substance ID:
329823996

Key Documents

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form

solid

color

white

mp

216-217 °C

solubility

H2O: soluble

SMILES string

Cl.NCCNC(=O)c1ccc(Cl)cc1

InChI

1S/C9H11ClN2O.ClH/c10-8-3-1-7(2-4-8)9(13)12-6-5-11;/h1-4H,5-6,11H2,(H,12,13);1H

InChI key

ARUMZUNJBHSOQQ-UHFFFAOYSA-N

Gene Information

human ... MAOB(4129)

Biochem/physiol Actions

Selective, reversible, orally-active MAO-B inhibitor which is devoid of indirect sympathomimetic activity.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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G P Bondiolotti et al.
Biochemical pharmacology, 50(1), 97-102 (1995-06-29)
To investigate whether the reversible monoamine oxidase-B (MAO-B) inhibitors lazabemide and Ro 16-6491 have any additional effect on monoamine uptake and release, in vitro experiments were performed on rat forebrain synaptosomes and blood platelets. The effects of the two drugs
Interactions of the novel inhibitors of MAO-B Ro 19-6327 and Ro 16-6491 with the active site of the enzyme.
A M Cesura et al.
Pharmacological research communications, 20 Suppl 4, 51-61 (1988-12-01)
B Vallès et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(10), 1101-1111 (1993-10-01)
1. Moclobemide, an inhibitor of monoamine oxidase, shows mixed MAO A/B inhibition in rat, but pure MAO A inhibition in man. This is attributed to a primary amine metabolite which inhibits MAO B in vitro, but which is not detected
E L Mullan et al.
Journal of neural transmission. Supplementum, 41, 307-311 (1994-01-01)
Ro 16-6491 is known to be a potent reversible inhibitor of human brain MAO-B. This compound and several analogues were tested for their effect on bovine liver MAO-B. It was found that in compounds where the amide bond of Ro
Ro 16-6491: a new reversible and highly selective MAO-B inhibitor protects mice from the dopaminergic neurotoxicity of MPTP.
M Da Prada et al.
Advances in neurology, 45, 175-178 (1987-01-01)
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