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R108

Ro 41-0960

solid

Synonym(s):

2′-Fluoro-3,4-dihydroxy-5-nitrobenzophenone

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About This Item

Empirical Formula (Hill Notation):
C13H8FNO5
CAS Number:
125628-97-9
Molecular Weight:
277.20
NACRES:
NA.77
PubChem Substance ID:
24278193
UNSPSC Code:
12352200
MDL number:
MFCD00078597
Form:
solid
Storage condition:
protect from light
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form

solid

Quality Segment

storage condition

protect from light

color

yellow

solubility

H2O: slightly soluble <0.7 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL, ethanol: soluble

storage temp.

2-8°C

SMILES string

Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F

InChI

1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H

InChI key

RQPAUNZYTYHKHA-UHFFFAOYSA-N

Gene Information

human ... COMT(1312)

Application

Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism.

Biochem/physiol Actions

Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Store tightly sealed at 4 °C, protected from exposure to light.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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