R130
RJR-2403 hemigalactarate
≥98% (HPLC), powder
Synonym(s):
N-Methyl-4-(3-pyridinyl]-3-buten-1-amine hemigalactarate
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About This Item
Empirical Formula (Hill Notation):
C20H28N4 · C6H10O8
CAS Number:
Molecular Weight:
534.60
UNSPSC Code:
12352200
MDL number:
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: 1 mg/mL, H2O: 20 mg/mL
storage temp.
2-8°C
SMILES string
CNCC\C=C\c1cccnc1
Biochem/physiol Actions
Neuronal nicotinic acetylcholine receptor agonist that displays CNS activity.
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Pharmacological characterization of RJR-2403: A nicotinic agonist with potential therapeutic benefit in the treatment of Alzheimer's disease.
Bencherif, M.
Cns Drug Reviews, 3, 325-325 (1997)
P M Lippiello et al.
The Journal of pharmacology and experimental therapeutics, 279(3), 1422-1429 (1996-12-01)
We have evaluated the physiological and behavioral effects of the CNS-selective nicotinic agonist (E)-N-methyl-4-(3-pyridinyl) -3-butene-1-amine (RJR-2403) using a number of different methods, including 1) reversal of pharmacologically induced amnesia in a step-through passive avoidance paradigm, 2) radial arm maze performance
M Bencherif et al.
The Journal of pharmacology and experimental therapeutics, 279(3), 1413-1421 (1996-12-01)
Increasing evidence for an involvement of nicotinic cholinergic systems in neurodegenerative disorders has stimulated the search for compounds with selectivity for CNS nicotinic ACh receptors (nAChRs). To this end, we have evaluated a number of nicotinic agonists for their ability