R1408
RU7
≥98% (HPLC)
Synonym(s):
5-[(2,3-Dibromo-5-ethoxy-4-hydroxyphenyl)methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid
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About This Item
Empirical Formula (Hill Notation):
C14H11Br2NO5S2
CAS Number:
Molecular Weight:
497.18
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
SMILES string
CCOC1=CC(/C=C2SC(N(CC(O)=O)C/2=O)=S)=C(Br)C(Br)=C1O
InChI
1S/C14H11Br2NO5S2/c1-2-22-7-3-6(10(15)11(16)12(7)20)4-8-13(21)17(5-9(18)19)14(23)24-8/h3-4,20H,2,5H2,1H3,(H,18,19)/b8-4+
InChI key
LMNXQDKRQCXSLB-XBXARRHUSA-N
Biochem/physiol Actions
RU7 is a selective inhibitor of bacterial β-clamp interaction with DNA polymerase POL III, and an inhibitor of a DNA polymerase sliding clamp
RU7 is a selective inhibitor of bacterial β-clamp interaction with DNA polymerase POL III, and an inhibitor of a DNA polymerase sliding clamp. Sliding clamps are proteins which function with diverse DNA polymerases, repair factors, and cell cycle-control proteins. RU7 binds to the peptide-binding pocket of the β-clamp and selectively inhibits Pol III, compared with Pol II and Pol IV.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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