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Merck
CN

R2153

RU 26752

≥98% (HPLC), solid

Synonym(s):

17α-Hydroxy-3-oxo-7α-propylpregn-4-ene-21-carboxylic acid γ-lactone

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About This Item

Empirical Formula (Hill Notation):
C25H36O3
CAS Number:
76676-33-0
Molecular Weight:
384.55
UNSPSC Code:
51111800
PubChem Substance ID:
329824013
MDL number:
MFCD06201853

Key Documents

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InChI

1S/C25H36O3/c1-4-5-16-14-17-15-18(26)6-10-23(17,2)19-7-11-24(3)20(22(16)19)8-12-25(24)13-9-21(27)28-25/h15-16,19-20,22H,4-14H2,1-3H3/t16-,19+,20+,22-,23+,24+,25-/m1/s1

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]34CCC(=O)O4)[C@]1([H])[C@H](CCC)CC5=CC(=O)CC[C@]25C

InChI key

MOFIIHQCTIJVBB-JEHIOXJOSA-N

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 20 mg/mL at 60 °C (warming up for 20 minutes)

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Mineralocorticoid receptor antagonist.
RU 26752 is a mineralocorticoid receptor antagonist.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H413

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
026K46264
026K46263
026K46262
026K46261
026K4626

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W G Luttge et al.
Endocrinology, 125(3), 1194-1203 (1989-09-01)
It is often implied that the various molecular, physiological, and behavioral responses to the glucocorticoid dexamethasone (DEX) are mediated in brain exclusively via the interactions of this synthetic steroid with the classical glucocorticoid (type II) receptor. The results reported in
M Kalimi et al.
The American journal of physiology, 258(5 Pt 1), E737-E739 (1990-05-01)
The effect of mineralocorticoid antagonist RU 26752 on the development and maintenance of hypertension produced by long-term administration of mineralocorticoid agonist aldosterone has been investigated. Uninephrectomized, saline-drinking male Sprague-Dawley rats were subcutaneously implanted with either placebo (control) pellets or pellets
L A Rollins-Smith et al.
Developmental immunology, 5(2), 145-152 (1997-01-01)
In recent years, integrative animal biologists and behavioral scientists have begun to understand the complex interactions between the immune system and the neuroendocrine system. Amphibian metamorphosis offers a unique opportunity to study dramatic hormone-driven changes in the immune system in
M Mirshahi et al.
Neuroendocrinology, 65(1), 70-78 (1997-01-01)
We studied the presence of the mineralocorticoid receptor (MCR) in the eye with the aid of a number of immunochemical techniques. Immunoblotting with a polyclonal antibody, directed against the rat renal MCR, revealed a single band of about 102 kD
M Mirshahi et al.
Biochemical and biophysical research communications, 219(1), 150-156 (1996-02-06)
Immunoblotting with a polyclonal antibody, directed against the mineralocorticoid receptor protein purified from rat kidney in presence of the receptor-specific ligand RU 26752, labeled a single 98-102 kDa band in soluble extracts from bovine retina and from cultured bovine retinal
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Product Information Sheet - R2153

Product Information Sheet

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