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R2153

RU 26752

Name: RU 26752
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

17α-Hydroxy-3-oxo-7α-propylpregn-4-ene-21-carboxylic acid γ-lactone

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₃₆O₃

CAS Number:

76676-33-0

Molecular Weight:

384.55

UNSPSC Code:

51111800

PubChem Substance ID:

329824013

MDL number:

MFCD06201853

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 20 mg/mL at 60 °C (warming up for 20 minutes)

storage temp.

−20°C

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]34CCC(=O)O4)[C@]1([H])[C@H](CCC)CC5=CC(=O)CC[C@]25C

InChI

1S/C25H36O3/c1-4-5-16-14-17-15-18(26)6-10-23(17,2)19-7-11-24(3)20(22(16)19)8-12-25(24)13-9-21(27)28-25/h15-16,19-20,22H,4-14H2,1-3H3/t16-,19+,20+,22-,23+,24+,25-/m1/s1

InChI key

MOFIIHQCTIJVBB-JEHIOXJOSA-N

Biochem/physiol Actions

Mineralocorticoid receptor antagonist.

RU 26752 is a mineralocorticoid receptor antagonist.

pictograms

GHS07

signalword

Warning

hcodes

H302,H413

pcodes

P273 - P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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High affinity binding and regulatory actions of dexamethasone-type I receptor complexes in mouse brain.

W G Luttge et al.

Endocrinology, 125(3), 1194-1203 (1989-09-01)

It is often implied that the various molecular, physiological, and behavioral responses to the glucocorticoid dexamethasone (DEX) are mediated in brain exclusively via the interactions of this synthetic steroid with the classical glucocorticoid (type II) receptor. The results reported in

Effects of antimineralocorticoid RU 26752 on steroid-induced hypertension in rats.

M Kalimi et al.

The American journal of physiology, 258(5 Pt 1), E737-E739 (1990-05-01)

The effect of mineralocorticoid antagonist RU 26752 on the development and maintenance of hypertension produced by long-term administration of mineralocorticoid agonist aldosterone has been investigated. Uninephrectomized, saline-drinking male Sprague-Dawley rats were subcutaneously implanted with either placebo (control) pellets or pellets

Involvement of glucocorticoids in the reorganization of the amphibian immune system at metamorphosis.

L A Rollins-Smith et al.

Developmental immunology, 5(2), 145-152 (1997-01-01)

In recent years, integrative animal biologists and behavioral scientists have begun to understand the complex interactions between the immune system and the neuroendocrine system. Amphibian metamorphosis offers a unique opportunity to study dramatic hormone-driven changes in the immune system in

Sulfhydryl groups are involved in the binding of agonists and antagonists to the human mineralocorticoid receptor.

A Souque et al.

The Journal of steroid biochemistry and molecular biology, 57(5-6), 315-321 (1996-03-01)

To investigate the role of sulfhydryl groups in the interaction of agonists and antagonists with the human mineralocorticoid receptor (hMR) the effect of methyl methanethiosulfonate (MMTS) on free and liganded-hMR was examined. hMR was expressed in insect cells (Sf9) using

Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium.

Saaeha Rauz et al.

Investigative ophthalmology & visual science, 44(4), 1643-1651 (2003-03-27)

In peripheral sodium-transporting tissues, the serum- and glucocorticoid-regulated kinase (SGK) isoform-1 is an early corticosteroid target gene in the activation of epithelial sodium channels (ENaCs). Sodium transport across the human ocular nonpigmented and pigmented ciliary epithelial bilayer (NPE-PE) is essential

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