R2283
Pepsin Reagent, Ready to Use, Antigen Retriever
suitable for immunohistochemistry
Synonym(s):
pepsin
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About This Item
UNSPSC Code:
12171500
NACRES:
NA.47
General description
Pepsin is used for proteolytic digestion of formalin-fixed paraffin-embedded (FFPE) tissue sections prior to the application of antibodies. In immunohistochemistry (IHC), the most commonly used fixatives such as formalin mask tissue antigens (cellular, membrane, and nuclear) by their intrinsic crosslinking. This masking results in poor or no staining in IHC. Pepsin digestion of FFPE tissue sections improves the accessibility of antibodies to tissue antigens. Ready to use pepsin reagent, antigen retriever has been used for antigen unmasking in immunohistochemistry.
Application
Pepsin is used for proteolytic digestion of formalin-fixed paraffin-embedded (FFPE) tissue sections prior to the application of antibodies in immunohistochemistry (IHC).It has been used to enhance the permeabilization of fungal cell walls during the fluorescence in situ hybridization (FISH) process and utilized during the RNA scope in situ hybridization process to perform antigen retrieval.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Skin Sens. 1
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
低风险生物材料
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The effect of low doses of cadmium and zinc chloride on the Blood-Testis Barrier of Sprague Dawley rats.
Redondo A, et al.
arXiv (2012)
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Baumbach C M, et al.
Journal of fungi (Basel, Switzerland), 8(1), 24-24 (2021)
Fetal testis organ culture reproduces the dynamics of epigenetic reprogramming in rat gonocytes.
Rwigemera A, et al.
Epigenetics & Chromatin, 10(1), 19-19 (2017)
Control of alveolar bone development, homeostasis, and socket healing by salt inducible kinases.
Tokavanich N, et al.
bioRxiv : the preprint server for biology, 2024-2009 (2024)
Codistribution of collagen type IV and laminin in liver fibrosis of elderly cadavers: immunohistochemical marker of perisinusoidal basement membrane formation.
Mak Ki M, et al.
The Anatomical Record, 296(6)A, 953-964 (2013)
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