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Merck
CN

R3151

Monoclonal Anti-Rhodopsin Kinase 1A antibody produced in mouse

clone G8, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-GRK1a

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About This Item

MDL number:
MFCD03457575
UNSPSC Code:
12352203
NACRES:
NA.44

Key Documents

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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

G8, monoclonal

form

buffered aqueous solution

species reactivity

rat, bovine, chicken, human, mouse

technique(s)

immunoprecipitation (IP): suitable
indirect immunofluorescence: suitable
western blot: suitable

UniProt accession no.

Q15835

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GRK1(6011)
mouse ... Grk1(24013)
rat ... Grk1(81760)

General description

GRK1 (rhodopsin kinase) is an enzyme that belongs to serine/threonine protein kinase family and expresses mainly in rod and cone photoreceptors. It has a crucial role in phosphorylation of photoactivated rhodopsin and hence starting steps in its deactivation. Monoclonal anti-rhodopsin kinase 1a antibody can be used in immunoprecipitation. Mouse anti-rhodopsin kinase 1a antibody reacts specifically with an epitope present in the C-terminal region of mouse, bovine, rat, chicken and human GRK1a. The product has shown no cross-reactivity with other G protein coupled kinases together with GRK1b.
Rhodopsin Kinase 1A encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation.

Immunogen

derived from human GRK1

Application

Monoclonal anti-rhodopsin kinase 1a antibody can be used in indirect immunofluorescence and western blotting.

Physical form

Supplied in phosphate buffered saline containing 0.05% sodium azide.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBB9776
041M1142
060M1225

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X Zhao et al.
FEBS letters, 454(1-2), 115-121 (1999-07-21)
The G protein-coupled receptor kinases (GRKs) are important enzymes in the desensitization of activated G protein-coupled receptors (GPCR). Seven members of the GRK family have been identified to date. Among these enzymes, GRK1 is involved in phototransduction and is the
X Zhao et al.
The Journal of biological chemistry, 273(9), 5124-5131 (1998-03-28)
The G protein-coupled receptor kinases (GRKs) are critical enzymes in the desensitization of activated G protein-coupled receptors. Six members of the GRK family have been identified to date. Among these enzymes, GRK1 (rhodopsin kinase) is involved in phototransduction and is

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