R3778
Anti-phospho-Retinoblastoma (pSer807) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-phospho-Rb (pSer807)
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
western blot: 0.25-0.75 μg/mL using Jurkat cells in high growth phase.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
target post-translational modification
phosphorylation (pSer807)
Quality Level
Gene Information
human ... RB1(5925)
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General description
RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on chromosome 13q14. It is a tumor-suppressor gene.
Immunogen
synthetic phosphopeptide derived from the region of human Rb that contains Ser807.
Biochem/physiol Actions
RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation.
Physical form
Solution in phosphate buffer, pH 7.4, containing 1 mg/mL BSA (protease and IgG-free) and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
Regulatory Information
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A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1
Eloy P, et al.
PLoS Genetics, 12(2) (2016)
Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development
Kashuba E and Mushtaq M
Experimental Oncology, 39(1), 12-16 (2017)
The Prognostic Value of the Immunohistochemical Expression of Phosphorylated RB and p16 Proteins in Association with Cyclin D1 and the p53 Pathway in a Large Cohort of Patients with Breast Cancer Treated with Taxane-based Adjuvant Chemotherapy
Gavressea T, et al.
Anticancer Research, 37(6), 2947-2957 (2017)
RB Loss Promotes Prostate Cancer Metastasis
Thangavel C, et al.
Cancer Research, 77(4), 982-995 (2017)
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