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Merck
CN

R6275

Anti-phospho-Retinoblastoma (pSer780) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02097166
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB CL
Citations:
5

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

mouse, human, rat

technique(s)

western blot (chemiluminescent): 1:1,000 using human fibroblasts synchronized by serum deprivation

UniProt accession no.

P06400

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer780)

Quality Level

200

Gene Information

human ... RB1(5925)
mouse ... Rb1(19645)
rat ... Rb1(24708)

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General description

RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on human chromosome 13q14. It is a tumor-suppressor gene.

Immunogen

synthetic peptide corresponding to residues around pSer780 of the human retinoblastoma tumor suppressor protein (Rb).

Biochem/physiol Actions

RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation.
Recognizes Rb phosphorylated at Ser780 and does not react with non-phosphorylated Rb. Does not react with Rb phosphorylated at other sites.

Physical form

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin, and 50% glycerol.

Preparation Note

Purified using protein A and affinity chromatography.

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Storage Class

10 - Combustible liquids

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
038K1630
076K1706
122K1351
030K0288
122K0953

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A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1
Eloy P, et al.
PLoS Genetics, 12(2) (2016)
Alessandro Poli et al.
Journal of cellular physiology, 232(9), 2550-2557 (2016-10-13)
Phosphatidylinositol (PI) signaling is an essential regulator of cell motility and proliferation. A portion of PI metabolism and signaling takes place in the nuclear compartment of eukaryotic cells, where an array of kinases and phosphatases localize and modulate PI. Among
Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development
Kashuba E and Mushtaq M
Experimental Oncology, 39(1), 12-16 (2017)
The Prognostic Value of the Immunohistochemical Expression of Phosphorylated RB and p16 Proteins in Association with Cyclin D1 and the p53 Pathway in a Large Cohort of Patients with Breast Cancer Treated with Taxane-based Adjuvant Chemotherapy
Gavressea T, et al.
Anticancer Research, 37(6), 2947-2957 (2017)
RB Loss Promotes Prostate Cancer Metastasis
Thangavel C, et al.
Cancer Research, 77(4), 982-995 (2017)

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