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R7753

Rhapontin

Name: Rhapontin
Brand: SIGMA

≥99% (HPLC), from rhubarb

Synonym(s):

3,3′,5-Trihydroxy-4′-methoxystilbene 3-O-β-D-glucoside, NSC 43321, Rhaponticin

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₄O₉

CAS Number:

155-58-8

Molecular Weight:

420.41

UNSPSC Code:

12352201

PubChem Substance ID:

24899400

EC Number:

205-845-0

MDL number:

MFCD00010117

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Properties

biological source

rhubarb

assay

≥99% (HPLC)

storage temp.

2-8°C

SMILES string

COc1ccc(\C=C\c2cc(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2)cc1O

InChI

1S/C21H24O9/c1-28-16-5-4-11(8-15(16)24)2-3-12-6-13(23)9-14(7-12)29-21-20(27)19(26)18(25)17(10-22)30-21/h2-9,17-27H,10H2,1H3/b3-2+/t17-,18-,19+,20-,21-/m1/s1

InChI key

GKAJCVFOJGXVIA-DXKBKAGUSA-N

Description

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

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Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK/Ay diabetic mice.

Jinlong Chen et al.

Planta medica, 75(5), 472-477 (2009-02-25)

We isolated several stilbene compounds including rhaponticin (3',5-dihydroxy-4'-methoxystilbene 3- O-beta- D-glucopyranoside) from extracts of rhubarb rhizomes. These compounds showed significant hypoglycemic effects in streptozotocin (STZ)-induced type 1 diabetic rats and mice. In this study, we investigated the effect of rhaponticin

Studies on the binding of rhaponticin with human serum albumin by molecular spectroscopy, modeling and equilibrium dialysis.

Yang Sun et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 87, 171-178 (2011-12-16)

Rhaponticin (RHA) possesses a variety of pharmacological activities including potent antitumor, antitumor-promoting, antithrombotic, antioxidant and vasorelaxant effects. In the solvation effect, RHA exhibited bathochromic shift in emission spectra with the increasing solvent polarity. The binding between RHA and HSA was

Assessment for the light-induced cis-trans isomerization of rhapontigenin and its glucoside rhaponticin by capillary electrophoresis and spectrometric methods.

Yang Hui et al.

Journal of chromatography. A, 1218(34), 5858-5866 (2011-07-26)

The light-induced cis-trans isomerization of rhapontigenin (RHA) and its glucoside rhaponticin (RHA-Glc) were evaluated under ultraviolet (UV) light irradiation. A simple and rapid capillary electrophoresis method was developed for the kinetic study of four stilbenes (both cis and trans form

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