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About This Item
UNSPSC Code:
12352203
Conjugate:
Quantum Red® conjugate
Clone:
HK14, monoclonal
Application:
FACS
Citations:
1
biological source
mouse
conjugate
Quantum Red® conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
HK14, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
flow cytometry: 10 μL using 1 × 106 cells
isotype
IgG2a
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... HLA-DRA(3122), HLA-DRB1(3123)
General description
HLA-DR is located on chromosome 6. It is composed of a heavy and light chain, which are two non-covalently associated subunits of molecular weight 33-36 kDa and 24-30 kDa, respectively. These class II antigens are expressed primarily on B cells, and on monocytes and activated T cells, and function in cell-cell recognition in regulation of the immune response.
The previously assigned protein identifier P01912 has been merged into P01911. Full details can be found on the UniProt database.
Immunogen
GM-1500 human tumor cell line
Biochem/physiol Actions
Recognizes HLA-DR, a product of the human major histocompatibility complex. The antibody is specific for a non-polymorphic HLA-DR determinant.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
Preparation Note
Quantum Red is a tandem fluorescent dye created by coupling R-phycoerythrin with Cy5 reactive dye. This red dye is efficiently excited at 488 nm and emits at 670 nm.
Legal Information
Texas Red is a registered trademark of Life Technologies
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Related Content
Instructions
Claudio Mauro et al.
Cell metabolism, 25(3), 593-609 (2017-02-14)
Low-grade systemic inflammation associated to obesity leads to cardiovascular complications, caused partly by infiltration of adipose and vascular tissue by effector T cells. The signals leading to T cell differentiation and tissue infiltration during obesity are poorly understood. We tested whether saturated