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Merck
CN

S002

Sigma-Aldrich

(±)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide

solid

Synonym(s):

(±)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene, (±)-8-Hydroxy-2-(dipropylamino)tetralin, (±)-8-OH-DPAT

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About This Item

Empirical Formula (Hill Notation):
C16H25NO · HBr
CAS Number:
87394-87-4
Molecular Weight:
328.29
MDL number:
MFCD00055158
UNSPSC Code:
12352100

Key Documents

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form

solid

color

white to tan

solubility

ethanol: 10 mg/mL
H2O: 5 mg/mL
0.1 M HCl: 7 mg/mL

SMILES string

Br[H].CCCN(CCC)C1CCc2cccc(O)c2C1

InChI

1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H

InChI key

BATPBOZTBNNDLN-UHFFFAOYSA-N

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Biochem/physiol Actions

Selective 5-HT1A serotonin receptor agonist.

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H Gozlan et al.
Nature, 305(5930), 140-142 (1983-09-08)
Binding studies with appropriate labelled ligands have revealed the existence of two types of serotonin (5-HT) receptor, 5-HT1 and 5-HT2, in the central nervous system of mammals. The 5-HT1 type is characterized by a higher affinity for agonists than for
E Mizuta et al.
European journal of pharmacology, 178(1), 125-127 (1990-03-13)
Subcutaneous injections of a 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), in monkeys induced distinct behavioural changes characterized by head weaving, hindlimb extension and upper limb fluttering. The effects were dose-dependent and were similar to the 5-HT syndrome induced in rats by
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.
D N Middlemiss et al.
European journal of pharmacology, 90(1), 151-153 (1983-05-20)

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