S003
1-(1-Naphthyl)piperazine hydrochloride
needles
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About This Item
Empirical Formula (Hill Notation):
C14H16N2 · HCl
Molecular Weight:
248.75
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C14H16N2.ClH/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16;/h1-7,15H,8-11H2;1H
SMILES string
Cl.C1CN(CCN1)c2cccc3ccccc23
InChI key
ZYVYPNZFOCZLEM-UHFFFAOYSA-N
form
needles
color
white
solubility
H2O: soluble, ethanol: slightly soluble
Gene Information
human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358)
Biochem/physiol Actions
5-HT1 serotonin receptor agonist; 5-HT2 serotonin receptor antagonist.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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P J Pauwels et al.
British journal of pharmacology, 123(1), 51-62 (1998-03-04)
1. The guinea-pig recombinant 5-hydroxytryptamine1B (gp 5-HT1B) receptor stably transfected in rat C6-glial cells was characterized by monitoring G-protein activation in a membrane preparation with agonist-stimulated [35S]-GTPgammaS binding. The intrinsic activity of 5-HT receptor ligands was compared with that determined
R W Fuller et al.
Research communications in chemical pathology and pharmacology, 51(1), 37-45 (1986-01-01)
1-(1-Naphthyl)piperazine (1-NP) had high affinity for tritiated serotonin, tritiated LSD (lysergic acid diethylamide) and tritiated spiperone binding sites in rat brain cortex in vitro. 1-NP at doses of 3-30 mg/kg i.p. decreased 5-hydroxyindoleacetic acid (5-HIAA) concentration in whole brain of
M S Herness et al.
The Journal of membrane biology, 173(2), 127-138 (2000-01-12)
Recently we reported that rat taste receptor cells respond to the neurotransmitter serotonin with an inhibition of a calcium-activated potassium current [17]. In the present study, this observation is confirmed and extended by studying the effects of an array of
E Béjar et al.
The Journal of pharmacy and pharmacology, 47(8), 637-642 (1995-08-01)
Biphasic cumulative concentration-response curves to 5-hydroxytryptamine (5-HT) and alpha-methyl-5-hydroxytryptamine (alpha-Me-5-HT) using rat stomach fundus in the presence of 50 microM pargyline suggested two sites of interaction (high and low affinity). The order of agonist potencies of 5-HT agonists for the
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