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S006

Ketanserin (+)-tartrate salt

Name: Ketanserin (+)-tartrate salt
Brand: SIGMA

≥97%, 5-HT2 serotonin receptor antagonist, solid

Synonym(s):

3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt, R 41468 (+)-tartrate salt

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₂FN₃O₃ · C₄H₆O₆

CAS Number:

83846-83-7

Molecular Weight:

545.51

NACRES:

NA.77

PubChem Substance ID:

24278121

UNSPSC Code:

12352202

EC Number:

281-062-8

MDL number:

MFCD00084651

Assay:

≥97%

Form:

solid

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Properties

Product Name

Ketanserin (+)-tartrate salt, ≥97%, solid

Quality Segment

100

assay

≥97%

form

solid

color

white

solubility

ethanol: 3 mg/mL, DMSO: 52 mg/mL (lit.)(lit.), 0.1 M HCl: 6 mg/mL (lit.)(lit.)

storage temp.

2-8°C

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=O)Nc4ccccc4C3=O

InChI

1S/C22H22FN3O3.C4H6O6/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1

InChI key

KMTLTEVOQLMYRS-LREBCSMRSA-N

Gene Information

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

Description

Application

Ketanserin (+)-tartrate salt has been used:

as a 5HT2A antagonist in Krebs-Henseleit buffer solution
for hormonal treatment to study the effects of exogenous manipulation of different hormonal systems in interaction with parasite infection on client′s behavior
to study the behavioural changes of incision pain rats

Biochem/physiol Actions

Ketanserin stimulates collagen synthesis and is involved in wound healing.

Selective 5-HT₂ serotonin receptor antagonist.

Selective 5-HT₂ serotonin receptor antagonist. Ketanserin significantly reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c