S0274
[D-Arg1, D-Trp7,9, Leu11]-Substance P acetate salt
≥97% (HPLC)
Synonym(s):
Spantide I
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About This Item
Empirical Formula (Hill Notation):
C75H108N20O13 · xC2H4O2
CAS Number:
Molecular Weight:
1497.79 (free base basis)
UNSPSC Code:
12352200
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCCCN)NC(=O)[C@@H]7CCCN7C(=O)[C@H](N)CCCNC(N)=N)C(N)=O
Gene Information
human ... TACR1(6869)
mouse ... TACR1(21336)
rat ... TACR1(24807)
Biochem/physiol Actions
Potent NK-1 tachykinin receptor antagonist.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Radomir Radomirov et al.
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The evacuative motor responses of the anal canal and recto-anal reflexes during defecation were studied in an isolated rat recto-anal model preparation using (i) partitioned organ bath, (ii) electrical stimulation, (iii) balloon distension and (iv) morphological techniques. Electrical field stimulation
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Molecular pain, 3, 30-30 (2007-10-27)
Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs). Inflammatory neuropeptides are suggested to be released from primary afferent nociceptors participating in
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The parafacial respiratory group (pFRG) in the rostral ventrolateral medulla of the newborn rat is predominantly composed of pre-inspiratory (Pre-I) neurons and is involved in respiratory rhythm generation. The subgroup located close to the ventral surface (at least partially overlapping