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Merck
CN

S0375

D-Saccharic acid 1,4-lactone monohydrate

≥98.0% (HPLC)

Synonym(s):

D-Glucaric acid-1,4-lactone, D-Saccharolactone

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About This Item

Empirical Formula (Hill Notation):
C6H8O7 · H2O
CAS Number:
61278-30-6
Molecular Weight:
210.14
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24899420
MDL number:
MFCD00149334
Beilstein/REAXYS Number:
85594

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Product Name

D-Saccharic acid 1,4-lactone monohydrate, ≥98.0% (HPLC)

InChI

1S/C6H8O7.H2O/c7-1-2(8)6(12)13-4(1)3(9)5(10)11;/h1-4,7-9H,(H,10,11);1H2/t1-,2-,3+,4+;/m1./s1

SMILES string

O.O[C@@H]1[C@@H](O)C(=O)O[C@@H]1[C@H](O)C(O)=O

InChI key

NPFKVZHSFSFLPU-QGBSHYGGSA-N

assay

≥98.0% (HPLC)

form

powder

impurities

≤10.0% water (Karl Fischer)

color

white

mp

91 - 93 °C ((196 - 199 °F ))

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

Quality Level

200

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Application

D-Saccharic acid 1,4-lactone monohydrate has been used as a constituent of phosphate buffer to block incidental β-glucuronidase activity in Streptococcus pneumoniae hyaluronan lyase (SpnHL) activity assay. It has also been used as a component of reaction mixture in Iduronidase activity assay and UDP-glucuronosyltransferase 1 (UGT1A1) inhibition assay.

General description

D-Saccharic acid 1,4-lactone monohydrate (DSAL) has an ability to inhibit the activity of β-glucuronidase enzyme.It also potentially inhibits Klotho deglycosylation of excitatory amino acid transporters (EAATs) and peptide transporters (PEPTs).

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000519553
0000500362
0000500362
0000312261
0000312261

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Syed Ahmad et al.
Current chemical genomics, 5, 13-20 (2011-06-07)
CPT-11 is a widely-used anti-cancer drug that is converted in vivo to its active metabolite, SN-38. In the liver, enzymes detoxify SN-38 by coupling it to a glucuronidate moiety and this inactive compound (SN-38G) is excreted into the gastrointestinal tract.
beta-Klotho as a Negative Regulator of the Peptide Transporters PEPT1 and PEPT2
Abousaab A, et al.
Cellular Physiology and Biochemistry, 40(5), 874-882 (2016)
Gertrud E Morlock et al.
Antioxidants (Basel, Switzerland), 10(1) (2021-01-21)
The antioxidative activity of Camelia sinensis tea and especially powdered tea extracts on the market, among others used as added value in functional foods, can considerably vary due to not only natural variance, but also adulteration and falsification. Thus, an
Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice
Wang D, et al.
Nature Biotechnology, 36(9), 839-839 (2018)
In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia
Chiou W, et al.
Xenobiotica, 44(3), 276-282 (2014)
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