S0375
D-Saccharic acid 1,4-lactone monohydrate
≥98.0% (HPLC)
Synonym(s):
D-Glucaric acid-1,4-lactone, D-Saccharolactone
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About This Item
Empirical Formula (Hill Notation):
C6H8O7 · H2O
CAS Number:
Molecular Weight:
210.14
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
85594
Quality Level
assay
≥98.0% (HPLC)
form
powder
impurities
≤10.0% water (Karl Fischer)
color
white
mp
91 - 93 °C ((196 - 199 °F ))
solubility
water: 50 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
SMILES string
O.O[C@@H]1[C@@H](O)C(=O)O[C@@H]1[C@H](O)C(O)=O
InChI
1S/C6H8O7.H2O/c7-1-2(8)6(12)13-4(1)3(9)5(10)11;/h1-4,7-9H,(H,10,11);1H2/t1-,2-,3+,4+;/m1./s1
InChI key
NPFKVZHSFSFLPU-QGBSHYGGSA-N
General description
D-Saccharic acid 1,4-lactone monohydrate (DSAL) has an ability to inhibit the activity of β-glucuronidase enzyme.It also potentially inhibits Klotho deglycosylation of excitatory amino acid transporters (EAATs) and peptide transporters (PEPTs).
Application
D-Saccharic acid 1,4-lactone monohydrate has been used as a constituent of phosphate buffer to block incidental β-glucuronidase activity in Streptococcus pneumoniae hyaluronan lyase (SpnHL) activity assay. It has also been used as a component of reaction mixture in Iduronidase activity assay and UDP-glucuronosyltransferase 1 (UGT1A1) inhibition assay.
Other Notes
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia
Chiou W, et al.
Xenobiotica, 44(3), 276-282 (2014)
Klotho preservation by Rhein promotes toll-like receptor 4 proteolysis and attenuates lipopolysaccharide-induced acute kidney injury
Bi F, et al.
Journal of Molecular Medicine, 96(9), 915-927 (2018)
Magnetic macroporous bead cellulose functionalised with recombinant hyaluronan lyase for controllable hyaluronan fragmentation
Kavsparova J, et al.
Process Biochemistry (Oxford, United Kingdom), 72, 105-111 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S0375-25G | 04061835367580 |
| S0375-5G | 04061832393100 |
| S0375-1G | 04061836830236 |
| S0375-250MG | 04061835367573 |