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Merck
CN

S0648

Sigma-Aldrich

Secretin porcine

~25 units/mg solid, from Porcine intestinal mucosa

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About This Item

Empirical Formula (Hill Notation):
C130H220N44O41
CAS Number:
17034-35-4
Molecular Weight:
3055.41
Beilstein:
741850
EC Number:
241-105-3
MDL number:
MFCD00133810
UNSPSC Code:
12352200

Key Documents

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biological source

Porcine intestinal mucosa

specific activity

~25 units/mg solid

packaging

vial of ~100 Crick-Harper-Raper units

solubility

H2O: soluble
saline: soluble

UniProt accession no.

P63298

storage temp.

2-8°C

SMILES string

[H]N[C@@H](CC(O)=O)C(O)=O.[H]N[C@@H](CC(O)=O)C(O)=O.[H]N[C@@H](CC(O)=O)C(O)=O.[H]N[C@@H](CC(O)=O)C(O)=O.[H]N[C@@H](CC(O)=O)C(O)=O.[H]N[C@@H](CC(O)=O)C(O)=O.[H]N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](C(C)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O

InChI

1S/C130H220N44O41.6C4H7NO4/c1-59(2)41-79(119(208)173-99(65(13)14)102(134)191)152-94(183)52-148-105(194)76(31-34-92(132)181)157-114(203)82(44-62(7)8)164-116(205)83(45-63(9)10)162-108(197)73(28-22-38-145-128(137)138)154-111(200)77(32-35-93(133)182)158-115(204)81(43-61(5)6)160-107(196)72(27-21-37-144-127(135)136)153-103(192)66(15)151-121(210)88(54-175)169-118(207)87(50-98(189)190)166-110(199)74(29-23-39-146-129(139)140)155-113(202)80(42-60(3)4)161-109(198)75(30-24-40-147-130(141)142)156-122(211)90(56-177)170-117(206)84(46-64(11)12)163-112(201)78(33-36-96(185)186)159-123(212)91(57-178)171-126(215)101(68(17)180)174-120(209)85(47-69-25-19-18-20-26-69)167-125(214)100(67(16)179)172-95(184)53-149-106(195)86(49-97(187)188)165-124(213)89(55-176)168-104(193)71(131)48-70-51-143-58-150-70;6*5-2(4(8)9)1-3(6)7/h18-20,25-26,51,58-68,71-91,99-101,175-180H,21-24,27-50,52-57,131H2,1-17H3,(H2,132,181)(H2,133,182)(H2,134,191)(H,143,150)(H,148,194)(H,149,195)(H,151,210)(H,152,183)(H,153,192)(H,154,200)(H,155,202)(H,156,211)(H,157,203)(H,158,204)(H,159,212)(H,160,196)(H,161,198)(H,162,197)(H,163,201)(H,164,205)(H,165,213)(H,166,199)(H,167,214)(H,168,193)(H,169,207)(H,170,206)(H,171,215)(H,172,184)(H,173,208)(H,174,209)(H,185,186)(H,187,188)(H,189,190)(H4,135,136,144)(H4,137,138,145)(H4,139,140,146)(H4,141,142,147);6*2H,1,5H2,(H,6,7)(H,8,9)/t66-,67+,68+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,99-,100-,101-;6*2-/m0000000/s1

InChI key

KYSAMAXXLYMNME-INRVZKLKSA-N

Gene Information

pig ... SCT(397464)

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Amino Acid Sequence

His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2

Biochem/physiol Actions

Stimulates secretion of carbonate-rich pancreatic fluid; relaxes smooth muscle

Preparation Note

Partially purified

Analysis Note

Activity determined by RIA using pure synthetic porcine secretin as standard.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
116H0624
099H1105
094H0863
048H1377
129H0983

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Mitsuyoshi Yamamoto et al.
Regulatory peptides, 178(1-3), 80-85 (2012-07-17)
The renin-angiotensin system (RAS) exists in the pancreas, but the role of RAS in the regulation of pancreatic exocrine secretion under physiological conditions has been little known. The present study addressed the RAS's effect on the pancreatic secretion by using
Xin-Yi Chen et al.
Neuroscience letters, 532, 29-32 (2012-11-15)
The paraventricular nucleus (PVN) of hypothalamus is a major integrative center in homeostatic control. Morphological studies have revealed a high level of secretin and secretin receptor expression in the PVN. To investigate the direct electrophysiological effects of secretin in the
Maoqing Dong et al.
Regulatory peptides, 180, 5-11 (2012-11-13)
Understanding of the structural importance of each position along a peptide ligand can provide important insights into the molecular basis for its receptor binding and biological activity. This has typically been evaluated using serial replacement of each natural residue with
Yasuhisa Mori et al.
Pancreas, 42(2), 187-192 (2013-02-15)
The aim of this study was to establish a minimally invasive and simple screening test for detection of pancreatic ductal adenocarcinoma (PDAC) using duodenal juice (DJ). Duodenal juice was collected prospectively before endoscopic retrograde cholangiopancreatography in 46 patients. A protease
Revathi Sekar et al.
General and comparative endocrinology, 181, 18-24 (2012-12-19)
Secretin (Sct), traditionally a gastrointestinal hormone backed by a century long research, is now beginning to be recognized also as a neuroactive peptide. Substantiation by recent evidence on the functional role of Sct in various regions of the brain, especially
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