S0827
Streptokinase C from Streptococcus sp.
buffered aqueous solution, ≥50,000 units/mg protein
recombinant
expressed in E. coli
Quality Level
form
buffered aqueous solution
specific activity
≥50,000 units/mg protein
storage temp.
−20°C
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Application
Streptokinase (SK) is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare. The product has been used to measure SK activity in brain heart infusion culture supernatant fluids of the various wild-type and mutant strains of Streptococcus dysgalactiae subsp. Equisimilis.
Biochem/physiol Actions
Streptokinase C is an extracellular enzyme that is produced by various strains of β-hemolytic streptococci. It is a single-chain polypeptide that exerts its fibrinolytic action indirectly by activating the circulatory plasminogen.
Physical form
Supplied as a frozen solution containing 60 mM phosphate buffer and 0.6 M glutamate. Albumin-free
Other Notes
One unit will liquify a standard clot of fibrinogen, plasminogen, and thrombin at pH 7.5 at 37 °C in 10 min.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
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Kerstin Steiner et al.
Infection and immunity, 70(7), 3627-3636 (2002-06-18)
Synthesis of the plasminogen activator streptokinase (SK) by group A streptococci (GAS) has recently been shown to be subject to control by two two-component regulators, covRS (or csrRS) and fasBCA. In independent studies, response regulator CovR proved to act as
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