S102
S-(−)-SKF-38393 hydrochloride
solid
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About This Item
Empirical Formula (Hill Notation):
C16H17NO2 · HCl
CAS Number:
Molecular Weight:
291.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m0./s1
SMILES string
Cl.Oc1cc2CCNC[C@@H](c3ccccc3)c2cc1O
InChI key
YEWHJCLOUYPAOH-UQKRIMTDSA-N
form
solid
optical activity
[α]27/D −14.8°, c = 1.7 in methanol(lit.)
color
tan
Biochem/physiol Actions
D1 dopamine receptor agonist; less active enantiomer of (±)-SKF-38393.
Disclaimer
Photosensitive
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Gnana P Krishnamoorthy et al.
Cancer discovery, 9(2), 264-281 (2018-10-12)
Translation initiation is orchestrated by the cap binding and 43S preinitiation complexes (PIC). Eukaryotic initiation factor 1A (EIF1A) is essential for recruitment of the ternary complex and for assembling the 43S PIC. Recurrent EIF1AX mutations in papillary thyroid cancers are
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