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Merck
CN

S1068

SB-215505

solid, >98% (HPLC)

Synonym(s):

6-Chloro-5-methyl-1-5-quinolycarbamoyl-indoline

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About This Item

Empirical Formula (Hill Notation):
C19H16N3OCl
CAS Number:
162100-15-4
Molecular Weight:
337.80
NACRES:
NA.77
PubChem Substance ID:
24278573
UNSPSC Code:
12352200
MDL number:
MFCD05664741

Key Documents

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InChI key

BPVGSWDWIRIUME-UHFFFAOYSA-N

SMILES string

Cc1cc2CCN(C(=O)Nc3ccnc4ccccc34)c2cc1Cl

InChI

1S/C19H16ClN3O/c1-12-10-13-7-9-23(18(13)11-15(12)20)19(24)22-17-6-8-21-16-5-3-2-4-14(16)17/h2-6,8,10-11H,7,9H2,1H3,(H,21,22,24)

assay

>98% (HPLC)

form

solid

color

off-white

solubility

DMSO: soluble ~11 mg/mL at 60 °C, H2O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

Gene Information

human ... HTR2B(3357)

Biochem/physiol Actions

Selective 5-HT2B serotonin receptor antagonist; 100-fold higher affinity at 2B versus 2C.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

新产品
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Certificates of Analysis (COA)

Lot/Batch Number
072M4625V
115K46144
115K46143
115K46142
115K46141

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Adam J Isabella et al.
Developmental cell, 53(3), 344-357 (2020-04-18)
Information flow through neural circuits often requires their organization into topographic maps in which the positions of cell bodies and synaptic targets correspond. To understand how topographic map development is controlled, we examine the mechanism underlying targeting of vagus motor

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