S1315
L-Serine
Synonym(s):
(S)-2-Amino-3-hydroxypropionic acid
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About This Item
Linear Formula:
HOCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
105.09
EC Number:
200-274-3
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
1721404
biological source
non-animal source
assay
≥98.5%
manufacturer/tradename
Ajinomoto
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
mp
222 °C (dec.) (lit.)
solubility
H2O: 50 mg/mL
suitability
suitable for manufacturing use
application(s)
pharmaceutical (small molecule)
SMILES string
N[C@@H](CO)C(O)=O
InChI
1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChI key
MTCFGRXMJLQNBG-REOHCLBHSA-N
General description
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to documentation for this product requires a confidentiality disclosure agreement.
Application
L-Serine is classified as a non-essential amino acid. It is used as a cell culture media component and raw material for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.
Biochem/physiol Actions
Precursor of glycine by serine hydroxymethyltransferase.
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Miyoshi Haruta et al.
Science (New York, N.Y.), 343(6169), 408-411 (2014-01-25)
Plant cells are immobile; thus, plant growth and development depend on cell expansion rather than cell migration. The molecular mechanism by which the plasma membrane initiates changes in the cell expansion rate remains elusive. We found that a secreted peptide
Kenji Hashimoto et al.
Progress in neuro-psychopharmacology & biological psychiatry, 29(5), 767-769 (2005-06-09)
Several lines of evidence suggest that D-serine, an endogenous agonist of the glycine site on the NMDA receptors, might play a role in the pathophysiology of schizophrenia. The purpose of this study was to determine whether levels of D- and
Jieun Kim et al.
Nature neuroscience, 17(1), 65-72 (2013-11-12)
Memory is supported by a specific ensemble of neurons distributed in the brain that form a unique memory trace. We previously showed that neurons in the lateral amygdala expressing elevated levels of cAMP response-element binding protein are preferentially recruited into