S1563
SKF-86466 hydrochloride
solid, ≥98% (HPLC)
Synonym(s):
6-Chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride
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About This Item
Linear Formula:
C11H14ClN·HCl
CAS Number:
Molecular Weight:
232.15
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98% (HPLC)
form
solid
color
white
solubility
H2O: 24 mg/mL
SMILES string
Cl.CN1CCc2cccc(Cl)c2CC1
InChI
1S/C11H14ClN.ClH/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13;/h2-4H,5-8H2,1H3;1H
InChI key
JKQKVNMNAIFCFS-UHFFFAOYSA-N
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
Application
SKF 86466 was used to study adrenoceptor signaling in rat limbic seizure models.
Biochem/physiol Actions
SKF 86466 binds specifically to α2-adrenoceptors at pre- and post-junctional sites but was also reported to antagonize α1-aderenoceptors in humans. The structural similarity of receptors enables SKF 86466 binding to 5-HT1A receptors.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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M S Hedrick et al.
Respiration physiology, 101(2), 129-137 (1995-08-01)
The purpose of this study was to test the hypothesis that respiratory and apneas induced by alpha 2 agonists in anesthetized goats are associated with an increase of upper airway expiratory-related activity, rather than a general depression of breathing. Activities
Ralph Clinckers et al.
Journal of neurochemistry, 115(6), 1595-1607 (2010-10-26)
Noradrenaline exerts inhibitory effects on seizure susceptibility. Subtype selective agonists and antagonists were used to identify the anticonvulsant hippocampal adrenoreceptors. Intrahippocampal dialysis was used for administration of all compounds, including pilocarpine for limbic seizure induction, and as the neurotransmitter sampling
S Sesoko et al.
The American journal of physiology, 274(4 Pt 2), R1119-R1124 (1998-05-12)
The inhibitory action of alpha 2-agonists on the cardiovascular neurons has been elucidated in the rostral ventrolateral medulla (RVLM) but not in the caudal ventrolateral medulla (CVLM). Our study aimed to clarify whether microinjection of clonidine into the CVLM elicits
M A Haxhiu et al.
Advances in experimental medicine and biology, 454, 467-473 (1999-01-16)
In these studies we determined the effects of local hypoxia confined to the superficial structures of the ventral medulla on cholinergic outflow to the airways. Studies were performed in alpha-chloralose anesthetized, paralyzed and mechanically ventilated cats. Topical application or microinjection
F P Tolentino-Silva et al.
Journal of applied physiology (Bethesda, Md. : 1985), 89(2), 437-444 (2000-08-05)
We studied the respiratory and blood pressure responses to chemical stimulation of two regions of the ventral brainstem in mice: the rostral and caudal ventrolateral medulla (RVLM and CVLM, respectively). Stimulation of the RVLM by microinjections of the excitatory amino
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