S1563
SKF-86466 hydrochloride
solid, ≥98% (HPLC)
Synonym(s):
6-Chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride
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About This Item
Linear Formula:
C11H14ClN·HCl
CAS Number:
Molecular Weight:
232.15
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
assay
≥98% (HPLC)
form
solid
color
white
solubility
H2O: 24 mg/mL
SMILES string
Cl.CN1CCc2cccc(Cl)c2CC1
InChI
1S/C11H14ClN.ClH/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13;/h2-4H,5-8H2,1H3;1H
InChI key
JKQKVNMNAIFCFS-UHFFFAOYSA-N
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
Application
SKF 86466 was used to study adrenoceptor signaling in rat limbic seizure models.
Biochem/physiol Actions
SKF 86466 binds specifically to α2-adrenoceptors at pre- and post-junctional sites but was also reported to antagonize α1-aderenoceptors in humans. The structural similarity of receptors enables SKF 86466 binding to 5-HT1A receptors.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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