biological source
human
recombinant
expressed in E. coli
Assay
>97% (SDS-PAGE)
form
lyophilized powder
mol wt
predicted mol wt ~8 kDa
storage condition
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CXCL12(6387)
Specificity
Mature human SDF-1α shares 100% amino acid sequence homology with rhesus macaque and feline SDF-1α.
Biochem/physiol Actions
SDF-1α/PBSF, a member of the α (CXC) chemokine family, is a chemoattractant for T lymphocytes and monocytes, but not neutrophils. SDF-1α/PBSF is highly conserved between species, with only one amino acid substitution between the human and mouse proteins. SDF-1α and SDF-1β are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the C-terminal of SDF-1β and absent from SDF-1α.. SDF-1/PBSF is a ligand for CXCR4 receptor that functions as a coreceptor for lymphocyte-tropic HIV-1 strains. SDF-1/PBSF is a powerful inhibitor of infection by lymphocyte-tropic HIV-1 strains.
Physical form
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoracetic acid containing 0.5 mg bovine serum albumin.
Analysis Note
The biological activity can be measured by its ability to chemoattract 5-10 day cultured human T lymphocytes or chemoattract BaF/3 human CXCR4 cells.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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