S190
Stromal Cell-Derived Factor 1α/pre-B Cell Growth Stimulating Factor human
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
SDF-1α/PBSF
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About This Item
UNSPSC Code:
51111800
MDL number:
biological source
human
recombinant
expressed in E. coli
assay
>97% (SDS-PAGE)
form
lyophilized powder
mol wt
predicted mol wt ~8 kDa
storage condition
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CXCL12(6387)
Biochem/physiol Actions
Mature human SDF-1α shares 100% amino acid sequence homology with rhesus macaque and feline SDF-1α.
SDF-1α/PBSF, a member of the α (CXC) chemokine family, is a chemoattractant for T lymphocytes and monocytes, but not neutrophils. SDF-1α/PBSF is highly conserved between species, with only one amino acid substitution between the human and mouse proteins. SDF-1α and SDF-1β are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the C-terminal of SDF-1β and absent from SDF-1α.. SDF-1/PBSF is a ligand for CXCR4 receptor that functions as a coreceptor for lymphocyte-tropic HIV-1 strains. SDF-1/PBSF is a powerful inhibitor of infection by lymphocyte-tropic HIV-1 strains.
Physical form
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoracetic acid containing 0.5 mg bovine serum albumin.
Analysis Note
The biological activity can be measured by its ability to chemoattract 5-10 day cultured human T lymphocytes or chemoattract BaF/3 human CXCR4 cells.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Kei Miyakawa et al.
The Journal of general virology, 89(Pt 12), 3137-3143 (2008-11-15)
There have been various attempts to redirect the cell entry receptor tropism of the murine leukemia virus vectors. We have recently reported the successful retargeting of the ecotropic Moloney murine leukemia virus vector. This vector (S3-D84K) contains a viral envelope
Abel Arul Nathan et al.
Tropical medicine & international health : TM & IH, 22(11), 1414-1427 (2017-09-05)
The underlying problem in lymphatic filariasis is irreversible swelling of the limbs (lymphoedema), which is a unique feature of lymphatic insufficiency. It is still unclear whether the natural ability of lymphatics to form functional lymphatic vasculature is achieved or attenuated
M Shirozu et al.
Genomics, 28(3), 495-500 (1995-08-10)
Stromal cell-derived factors 1 alpha and 1 beta are small cytokines belonging to the intercrine CXC subfamily and originally isolated from a murine bone-marrow stroma cell line by the signal sequence trap method. cDNA and genomic clones of human SDF1
C C Bleul et al.
Nature, 382(6594), 829-833 (1996-08-29)
Chemokines are chemotactic cytokines that activate and direct the migration of leukocytes. There are two subfamilies, the CXC and the CC chemokines. We recently found that the CXC-chemokine stromal cell-derived factor-1 (SDF-1) is a highly efficacious lymphocyte chemoattractant. Chemokines act
E Oberlin et al.
Nature, 382(6594), 833-835 (1996-08-29)
A putative chemokine receptor that we previously cloned and termed LESTR has recently been shown to function as a co-receptor (termed fusin) for lymphocyte-tropic HIV-1 strains. Cells expressing CD4 became permissive to infection with T-cell-line-adapted HIV-1 strains of the syncytium-inducing
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