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Merck
CN

S2671

Suramin sodium salt

≥98% (HPLC)

Synonym(s):

Suramine sodium salt

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About This Item

Empirical Formula (Hill Notation):
C51H34N6Na6O23S6
CAS Number:
129-46-4
Molecular Weight:
1429.17
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24277738
EC Number:
204-949-3
Beilstein/REAXYS Number:
3694087
MDL number:
MFCD00210217

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Product Name

Suramin sodium salt, ≥98% (HPLC)

InChI

1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6

InChI key

VAPNKLKDKUDFHK-UHFFFAOYSA-H

SMILES string

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1ccc(cc1NC(=O)c2cccc(NC(=O)Nc3cccc(c3)C(=O)Nc4cc(ccc4C)C(=O)Nc5ccc(c6cc(cc(c56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c2)C(=O)Nc7ccc(c8cc(cc(c78)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O

assay

≥98% (HPLC)

form

powder

impurities

<15% water (Karl Fischer)

color

white to light brown

solubility

H2O: >10 mg/mL

Quality Level

200

Gene Information

human ... EGF(1950), FGF1(2246), P2RX1(5023), P2RY1(5028), PDGFA(5154), PLD1(5337)

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Application

Suramin sodium salt has been used:
  • as a potent blocker of rat P2Y2 purinergic receptor
  • to study its effects on short circuit current (Isc) across strial marginal cells
  • to show its effects on initial burst of glial activity
  • to assess its neuroprotective potential in rats
  • as a purinoceptor inhibitor, to explore the mechanism of action of extracellular adenosine triphosphate (eATP)

Biochem/physiol Actions

Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity.

General description

Suramin is an antiparasitic drug, which blocks endothelial cell proliferation and increases tyrosine phosphorylation of many signalling proteins. It is associated with urticaria, paresthesias, vomiting and neurologic toxicity. Suramin is used to treat trypanosomiasis and onchocerciasis. It functions as an inhibitor of heparanase and also exhibits anti-AIDS (acquired immunodeficiency syndrome) property.

Other Notes

To gain a comprehensive understanding of our extensive range of Oligosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

wgk

WGK 3

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000450248
0000448617
0000450248
0000448617
0000431561

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Gabriela M Rozanski et al.
The European journal of neuroscience, 36(10), 3314-3321 (2012-08-01)
Somatic sensory neuron somata are located within the dorsal root ganglia (DRG) and are mostly ensheathed by individual satellite glial cell sheets. It has been noted, however, that a subpopulation of these DRG somata are intimately associated, separated only by
Suramin reduces infarct volume in a model of focal brain ischemia in rats
Kharlamov A, et al.
Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale, 147(3), 353-359 (2002)
Inorganic polyphosphate regulates neuronal excitability through modulation of voltage-gated channels
Stotz SC, et al.
Molecular Brain, 7(1), 42-42 (2014)
Drugs That Inhibit Signalling Pathways for Tumor Cell Growth and Proliferation
Medicinal Chemistry of Anticancer Drugs, 251-305 (2008)
James M McCarthy et al.
PloS one, 8(1), e55282-e55282 (2013-02-06)
Prion diseases, also known as transmissible spongiform encephalopathies, are a group of fatal neurodegenerative diseases that include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jakob disease (CJD) in humans. The 'protein only hypothesis' advocates that PrP(Sc), an
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Product Information Sheet - S2671

Product Information Sheet

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