Key Documents

View All Documentation

S2812

SNC80

Name: SNC80
Brand: SIGMA

≥98% (HPLC), δ opioid receptor agonist, solid

Synonym(s):

(+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide, SNC 80, SNC-80

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₈H₃₉N₃O₂

CAS Number:

156727-74-1

Molecular Weight:

449.63

UNSPSC Code:

12352200

PubChem Substance ID:

24278698

NACRES:

NA.77

MDL number:

MFCD00672673

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

SNC80, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: soluble

SMILES string

CCN(CC)C(=O)c1ccc(cc1)[C@H](N2C[C@H](C)N(CC=C)C[C@H]2C)c3cccc(OC)c3

InChI

1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27?/m0/s1

InChI key

KQWVAUSXZDRQPZ-QNWUEUMSSA-N

Gene Information

human ... OPRD1(4985)
mouse ... Oprd1(18386)
rat ... Oprd1(24613), Oprm1(25601)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Bioactive Small Molecules

Application

Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.⁵

Biochem/physiol Actions

SNC80 is a δ opioid receptor agonist.

SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.² It also acts as anti-depressant³, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.⁴

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling.

Richard M van Rijn et al.

The Journal of pharmacology and experimental therapeutics, 344(1), 179-188 (2012-10-26)

Drugs targeting G-protein-coupled receptors (GPCRs) make up more than 25% of all prescribed medicines. The ability of GPCRs to form heteromers with unique signaling properties suggests an entirely new and unexplored pool of drug targets. However, current in vitro assays

The development of a mouse model of mTBI-induced post-traumatic migraine, and identification of the delta opioid receptor as a novel therapeutic target.

Laura S Moye et al.

Cephalalgia : an international journal of headache, 39(1), 77-90 (2018-05-18)

Post-traumatic headache is the most common and long-lasting impairment observed following mild traumatic brain injury, and frequently has migraine-like characteristics. The mechanisms underlying progression from mild traumatic brain injury to post-traumatic headache are not fully understood. The aim of this

The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions.

Akiyoshi Saitoh et al.

Behavioural brain research, 223(2), 271-279 (2011-05-14)

We previously reported that the δ opioid receptor (DOP) agonists SNC80 and TAN-67 produce potent antidepressant-like and antinociceptive effects in rodents. However, SNC80 produced convulsive effects. Recently, we succeeded in synthesizing a novel DOP agonist called KNT-127. The present study

Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats.

Josimari M DeSantana et al.

Pain, 148(1), 84-93 (2009-12-01)

Transcutaneous electrical nerve stimulation (TENS) is a treatment for pain that involves placement of electrical stimulation through the skin for pain relief. Previous work from our laboratory shows that repeated application of TENS produces analgesic tolerance by the fourth day

δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization.

Chihiro Nozaki et al.

The Journal of pharmacology and experimental therapeutics, 342(3), 799-807 (2012-06-16)

N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5859) and N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5747) are novel δ-opioid agonists that show good oral bioavailability and analgesic and antidepressive effects in the rat and represent potential drugs for chronic pain treatment. Here, we used genetic approaches to investigate molecular mechanisms

View All Related Papers

Global Trade Item Number

SKU	GTIN
S2812-5MG	04061832559575
S2812-25MG	04061832559568

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service