S3066
SKF-89626 hydrobromide
>98% (HPLC), solid
Synonym(s):
4-(3,4-Dihydroxyphenyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine
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About This Item
Empirical Formula (Hill Notation):
C13H13NO2S · HBr
Molecular Weight:
328.22
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C13H13NO2S.BrH/c15-11-2-1-8(5-12(11)16)10-6-14-7-13-9(10)3-4-17-13;/h1-5,10,14-16H,6-7H2;1H
SMILES string
Br[H].Oc1ccc(cc1O)C2CNCc3sccc23
InChI key
QAIGGSDECIJPNW-UHFFFAOYSA-N
assay
>98% (HPLC)
form
solid
color
white
solubility
H2O: soluble 11 mg/mL
Gene Information
human ... DRD1(1812)
Application
SKF-89626 hydrobromide may be used in dopaminergic cell signaling studies.
Biochem/physiol Actions
D1 dopamine receptor agonist.
SKF-89626 is an isoquinoline derivative that fully antagonizes dopamine D1 receptor and stimulates adenylate cyclase and modulates dopaminergic-mediated cell responses.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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E B Nielsen et al.
European journal of pharmacology, 160(2), 253-262 (1989-01-31)
Dopamine (DA) D-1 and D-2 receptor agonists and antagonists were characterized in receptor binding and adenylate cyclase assays with respect to affinity, selectivity and efficacy. The ability of the ligands to interact with the discriminative stimulus effects of d-amphetamine (AMPH)
P H Andersen et al.
European journal of pharmacology, 188(6), 335-347 (1990-06-12)
Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds
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