S3136
[pGlu6]-Substance P Fragment 6-11
≥95% (HPLC)
Synonym(s):
pGlu-Phe-Phe-Gly-Leu-Met-NH2
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About This Item
Empirical Formula (Hill Notation):
C36H49N7O7S
CAS Number:
Molecular Weight:
723.88
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥95% (HPLC)
UniProt accession no.
storage temp.
−20°C
SMILES string
CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C3CCC(=O)N3)C(N)=O
Gene Information
human ... TAC1(6863)
Biochem/physiol Actions
Substance P agonist; increased blood pressure when injected into cerebral ventricles of rat.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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W A Turski et al.
The International journal of biochemistry, 17(10), 1097-1101 (1985-01-01)
Peptidase(s) activity of different subcellular fractions isolated from cortex, hippocampus, midbrain, thalamus with hypothalamus, cerebellum and medulla oblongata exerted against less than Glu SP6-11 (3H-Phen8) was evaluated in "low-ionic" and similar (in composition) to both extracellular and intracellular conditions. The
Conformational studies on substance P. C-terminal pentapeptide pGlu-Phe-Phe-Gly-Leu-Met NH2.
M Cotrait et al.
Biochemical and biophysical research communications, 109(4), 1123-1128 (1982-12-31)
O Gaffori et al.
Experientia, 40(1), 89-91 (1984-01-15)
N-terminal and C-terminal fragments of substance P (SP) have been shown to exert opposite effects on antinociception, grooming and fighting in mice. The present experiments explored whether these findings could be generalized to passive avoidance behavior. Substance P (SP-(1-11] and
M E Hall et al.
Peptides, 4(5), 763-768 (1983-09-01)
Most of the biological actions of substance P (SP) have been thought to be mediated by the carboxy-terminal portion of the peptide. Some of the behavioral effects produced by exogenous SP exhibit a strikingly different structure-activity relationship. The N-terminal heptapeptide
R Laufer et al.
Journal of medicinal chemistry, 29(7), 1284-1288 (1986-07-01)
Substitution of a single amino acid residue, proline for glycine-9 in [pGlu6]SP6-11, a hexapeptide analogue of substance P, confers on the peptide selective agonist activity toward the SP-P receptor subtype. [pGlu6,Pro9]SP6-11 had 20% and 75% of the activity of [pGlu6]SP6-11
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