S3136
[pGlu6]-Substance P Fragment 6-11
≥95% (HPLC)
Synonym(s):
pGlu-Phe-Phe-Gly-Leu-Met-NH2
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About This Item
Empirical Formula (Hill Notation):
C36H49N7O7S
CAS Number:
Molecular Weight:
723.88
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C3CCC(=O)N3)C(N)=O
assay
≥95% (HPLC)
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TAC1(6863)
Biochem/physiol Actions
Substance P agonist; increased blood pressure when injected into cerebral ventricles of rat.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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M E Hall et al.
Peptides, 5(1), 85-89 (1984-01-01)
Substance P (SP) significantly reduced fighting in mice made aggressive by prolonged isolation. The N-terminal heptapeptide fragment SP (1-7) also reduced fighting. The C-terminal fragment SP(4-11) was without activity, while the shorter C-terminal fragment analog less than E-SP(7-11) significantly increased
U Wormser et al.
Neuropeptides, 16(1), 41-49 (1990-05-01)
Five synthetic N-methylated analogs (II-V) of the C-terminal hexapeptide analog of substance P (SP), [pGlu6]SP6-11 (I) were evaluated for their metabolic stability and in vitro spasmogenic activity. The metabolic resistance of the analogs was tested by two SP degrading systems
The pressor response to substance P and hexapeptide [pGlu6]SP 6--11 injections into the cerebral ventricles in rats.
W Z Traczyk et al.
Neuropharmacology, 19(7), 607-611 (1980-07-01)
Y Iwabuchi et al.
Japanese journal of pharmacology, 58(3), 325-328 (1992-03-01)
The sialogogic response of submandibular glands to analogs of the C-terminal hexapeptide of substance P with various amino acids at the N-terminus was investigated in urethane-anesthetized rats. The rank order of potencies was as follows: SP greater than (pGlu6)SP6-11 much
R U Hasenöhrl et al.
Peptides, 11(1), 163-167 (1990-01-01)
Experiments were performed to investigate the effects of intraperitoneally administered undecapeptide substance P (SP), its N-terminal fragment SP(1-7) (SPN) and the C-terminal analog [pGlu6]-SP(6-11) (SPC) on inhibitory avoidance learning, using a one-trial up-hill avoidance task. In Experiment 1 rats were
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