S3638
Ser-Glu
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About This Item
Empirical Formula (Hill Notation):
C8H14N2O6
CAS Number:
Molecular Weight:
234.21
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C8H14N2O6/c9-4(3-11)7(14)10-5(8(15)16)1-2-6(12)13/h4-5,11H,1-3,9H2,(H,10,14)(H,12,13)(H,15,16)
SMILES string
NC(CO)C(=O)NC(CCC(O)=O)C(O)=O
InChI key
LAFKUZYWNCHOHT-UHFFFAOYSA-N
storage temp.
−20°C
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Laura Cipolla et al.
Future medicinal chemistry, 2(4), 587-599 (2011-03-24)
Several glycoprocessing enzymes and glycoreceptors have been recognized as important targets for therapeutic intervention. This concept has inspired the development of important classes of therapeutics, such as anti-influenza drugs inhibiting influenza virus neuraminidase, anti-inflammatory drugs targeting lectin-sialyl-Lewis X interaction and
T Tsukida et al.
Journal of medicinal chemistry, 41(22), 4279-4287 (1998-10-23)
We have previously found that heterochiral fucodipeptides, L-Ser-D-Glu (3a) and D-Ser-L-Glu (3b), exhibited up to 20-100 times more potency than a sialyl Lewis X (sLeX, 1) and a 3'-sulfated Lewis X analogue (2) toward E-selectin binding and have also proposed
T Tsukida et al.
Journal of medicinal chemistry, 40(22), 3534-3541 (1997-11-14)
We have rationally designed a sLe(x) mimetic based on molecular modeling, synthesized type II and type II' beta-turn dipeptides (3a,b), and evaluated their biological profiles both in vitro and in vivo. Against E-selectin-sLe(x) binding, the type II beta-turn dipeptide L-Ser-D-Glu
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