S3826
Staphostatin B from Staphylococcus aureus
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About This Item
NACRES:
NA.77
UNSPSC Code:
12352202
Biochem/physiol Actions
Staphostatins are a novel group of inhibitors with a unique specificity for the regulation of staphopains, Staphylococcus spp. cysteine proteinases. Staphostatin A and staphostatin B from S. aureus have been characterized in details. Staphostatins interact specifically with this target proteinases forming tight 1:1 and stable non-covalent complex, staphostain A with staphopain A and staphostain B with staphopain B with no cross interaction observed and with very narrow specificity limited to staphopains
The loss of staphostatin B (SspC) expression in S. aureus and the subsequent increase in secreted protease staphopain B (SspB) activity resulted in numerous defects including reduced growth, decreased autolytic activity, resistance to lysis by S. aureus phages, and the inability to secrete proteins into the extracellular matrix.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Lindsey N Shaw et al.
Journal of bacteriology, 187(5), 1751-1762 (2005-02-18)
The cytoplasmic protein SspC of Staphylococcus aureus, referred to as staphostatin B, is a very specific, tightly binding inhibitor of the secreted protease staphopain B (SspB). SspC is hypothesized to protect intracellular proteins against proteolytic damage by prematurely folded and
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