S3922
[Methyl-D-Phe6, D-Trp7,9, Leu10-psi(CH2NH)Leu11]-Substance P Fragment 6-11
≥97% (HPLC)
Synonym(s):
Methyl-D-Phe-D-Trp-Phe-D-Trp-Leu-psi[CH2NH]-Leu-NH2
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About This Item
Empirical Formula (Hill Notation):
C53H67N9O5
CAS Number:
Molecular Weight:
910.16
UNSPSC Code:
12352200
MDL number:
SMILES string
CN[C@H](Cc1ccccc1)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](Cc5c[nH]c6ccccc56)C(=O)N[C@H](CN[C@@H](CC(C)C)C(N)=O)CC(C)C
assay
≥97% (HPLC)
composition
Peptide content, ~70%
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TAC1(6863)
Biochem/physiol Actions
This substance P analog inhibited small-cell lung cancer proliferation in vitro and in vivo.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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A Orosz et al.
International journal of cancer, 60(1), 82-87 (1995-01-03)
Human small-cell lung-cancer cells (SCLC) produce and secrete gastrin-releasing peptide (GRP), the mammalian equivalent of bombesin (BN). There is some evidence to suggest that GRP is an autocrine regulator of SCLC cell growth. In the search for potent BN antagonists
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