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Merck
CN

S4152

[D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P acetate salt

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C75H108N20O13 · xC2H4O2
CAS Number:
143077-65-0
Molecular Weight:
1497.79 (free base basis)
UNSPSC Code:
12352202
PubChem Substance ID:
329824540
NACRES:
NA.26
MDL number:
MFCD00133837

Key Documents

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Product Name

[D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P acetate salt, ≥97% (HPLC)

SMILES string

CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCCCN)NC(=O)[C@H]7CCCN7C(=O)[C@H](N)CCCNC(N)=N)C(N)=O

InChI key

RXTRFXUUDKVCOG-FDUGBFHGSA-N

InChI

1S/C75H108N20O13.C2H4O2/c1-42(2)35-55(64(80)98)89-67(101)56(36-43(3)4)90-69(103)59(39-46-41-85-51-23-11-9-20-48(46)51)93-68(102)57(37-44-17-6-5-7-18-44)91-70(104)58(38-45-40-84-50-22-10-8-19-47(45)50)92-66(100)52(27-29-62(78)96)86-65(99)53(28-30-63(79)97)87-71(105)61-26-16-34-95(61)74(108)54(24-12-13-31-76)88-72(106)60-25-15-33-94(60)73(107)49(77)21-14-32-83-75(81)82;1-2(3)4/h5-11,17-20,22-23,40-43,49,52-61,84-85H,12-16,21,24-39,76-77H2,1-4H3,(H2,78,96)(H2,79,97)(H2,80,98)(H,86,99)(H,87,105)(H,88,106)(H,89,101)(H,90,103)(H,91,104)(H,92,100)(H,93,102)(H4,81,82,83);1H3,(H,3,4)/t49-,52+,53+,54+,55+,56+,57+,58-,59-,60-,61+;/m1./s1

assay

≥97% (HPLC)

storage temp.

−20°C

Biochem/physiol Actions

Substance P antagonist

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
042H5805
042H58051

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J W Brock et al.
Microvascular research, 41(1), 24-28 (1991-01-01)
The effects of substance P (SP) on microvessels in the cremaster of sodium pentobarbital-anesthetized male, Sprague-Dawley rats were investigated using closed-circuit television microscopy. Topically added SP (bath concentrations of 10(-13) to 10(-8) M) caused significant dilation of small arterioles. SP
J W Brock et al.
Regulatory peptides, 43(1-2), 65-71 (1993-01-22)
Substance P, which is present in small nerve terminals and proximal to microvessels in rat strated muscle, may have a vasodilator role if released into the microcirculation. Male, Sprague-Dawley rats were anesthetized with sodium pentobarbital (50 mg/kg, i.p.) and the
Hyun-Sook Hong et al.
Archives of pharmacal research, 34(12), 2003-2006 (2012-01-03)
Bone marrow is a reservoir for hematopoietic stem cells, endothelial precursor cells, and bone marrow stromal cells (also generally called mesenchymal stem cells), whose positive role in tissue repair is highly anticipated. In this report, we introduce a novel function
T W Moody et al.
Peptides, 16(6), 1133-1140 (1995-01-01)
The effects of neuromedin B (NMB) on C6 glioma cells were investigated. NMB bound with high affinity (IC50 = 1 nM) to C6 cells whereas BN and GRP were less potent (IC50 = 40 and 100 nM). NMB (1 nM)
Jensen, R.T., et al.
Nature, 209, 61-61 (1984)

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