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S4197

Anti-Sirt6 (C-terminal) antibody produced in rabbit

Name: Anti-Sirt6 (C-terminal) antibody produced in rabbit
Brand: SIGMA

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-NAD-dependent deacetylase sirtuin 6, Anti-SIR2-like protein 6, Anti-SIR2L6

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, WB

Citations:

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Properties

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~40 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

indirect immunofluorescence: suitable, western blot: 0.5-1 μg/mL using whole extracts of human U87 cells, western blot: 2.5-5 μg/mL using human HeLa cells

UniProt accession no.

Q8N6T7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SIRT6(51548)

Description

General description

Sirtuin 6 (Sirt6) is a nuclear, chromatin-associated protein. Sirt6 is a member of Sir2 gene family. It is broadly expressed with the highest levels in muscle, brain and heart.

Immunogen

synthetic peptide corresponding to amino acids 330-348 of human Sirt6.

Application

Anti-Sirt6 (C-terminal) antibody has been used in

immunoblotting
immunofluorescence
western blotting
immunohistochemistry

Biochem/physiol Actions

Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a NAD⁺ -dependent protein deacetylase but displays auto-ADP-ribosyltransferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

常规特殊物品

低风险生物材料

常规特殊物品

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Global Trade Item Number

SKU	GTIN
S4197-200UL	04061837795138