S4568
SCH 58261
≥98% (HPLC), adenosine receptor antagonist, solid
Synonym(s):
7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
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About This Item
Empirical Formula (Hill Notation):
C18H15N7O
CAS Number:
Molecular Weight:
345.36
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
SCH 58261, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
color
off-white
solubility
DMSO: soluble >10 mg/mL, H2O: insoluble
SMILES string
Nc1nc2n(CCc3ccccc3)ncc2c4nc(nn14)-c5ccco5
InChI
1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)
InChI key
UTLPKQYUXOEJIL-UHFFFAOYSA-N
Application
SCH 58261 was used to block A2α adenosine receptor to study the signaling by prostatic acid phosphatase in neurons.4
Biochem/physiol Actions
A2A adenosine receptor antagonist.
SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease.
Features and Benefits
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Cristiani F Bortolatto et al.
Metabolic brain disease, 32(6), 1919-1927 (2017-08-11)
The aim of the present study was to investigate the effects of SCH58261, a selective adenosine A
Mushtaq A Ansari et al.
Molecular and cellular neurosciences, 82, 76-87 (2017-05-04)
Autism spectrum disorder (ASD) is neurodevelopmental disorders characterized by stereotypical repetitive behavior, impaired social interaction, and deficits in communication. The BTBR T
Sheikh F Ahmad et al.
Journal of neuroimmunology, 311, 59-67 (2017-08-16)
Autism is a complex heterogeneous neurodevelopmental disorder; previous studies have identified altered immune responses among individuals diagnosed with autism. An imbalance in the production of pro- and anti-inflammatory cytokines and transcription factors plays a role in neurodevelopmental behavioral and autism
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S4568-25MG | 04061832093512 |
| S4568-5MG | 04061836927660 |