S4570
Sulochrin
≥98% (HPLC), solid
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About This Item
Empirical Formula (Hill Notation):
C17H16O7
CAS Number:
Molecular Weight:
332.30
UNSPSC Code:
51111800
PubChem Substance ID:
MDL number:
InChI
1S/C17H16O7/c1-8-4-11(19)15(12(20)5-8)16(21)14-10(17(22)24-3)6-9(18)7-13(14)23-2/h4-7,18-20H,1-3H3
SMILES string
COC(=O)c1cc(O)cc(OC)c1C(=O)c2c(O)cc(C)cc2O
InChI key
YJRLSCDUYLRBIZ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
solubility
DMF: soluble, DMSO: soluble, ethanol: soluble, methanol: soluble
antibiotic activity spectrum
fungi
mode of action
protein synthesis | interferes
storage temp.
2-8°C
Application
Sulochrin was used as standard in LC/ESI for quantification of analytes from moldy food samples.
Biochem/physiol Actions
Antibiotic from Aspergillus and Penicillium sp. Fungal metabolite; VEGF inhibitor and anti-angiogenic that inhibits the VEGF-induced tube formation of human umbilical vein endothelial cells.
Sulochrin, a metabolite of Aspergillus terreus and Penicillium sp., has weak anti-bacterial and anti-fungal properties. It inhibits the degranulation of eosinophils induced by the platelet activating factor.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation.
H Ohashi et al.
Bioorganic & medicinal chemistry letters, 9(14), 1945-1948 (1999-08-18)
Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and
Sulochrin inhibits eosinophil degranulation.
H Ohashi et al.
The Journal of antibiotics, 50(11), 972-974 (1998-05-21)
J Y Liu et al.
Journal of biotechnology, 114(3), 279-287 (2004-11-04)
Aspergillus fumigatus CY018 was recognized as an endophytic fungus for the first time in the leaf of Cynodon dactylon. By bioassay-guided fractionation, the EtOAc extract of a solid-matrix steady culture of this fungus afforded two new metabolites, named asperfumoid (1)
Robin D Couch et al.
Journal of biotechnology, 108(2), 171-178 (2004-05-08)
Elimination of undesirable co-metabolites from industrial fermentations is often required due to the toxicities associated with the contaminants and/or due to difficulties in removing the contaminants during downstream processing. Sulochrin is a co-metabolite produced during the Aspergillus terreus lovastatin fermentation.
Michael Sulyok et al.
Analytical and bioanalytical chemistry, 389(5), 1505-1523 (2007-09-18)
This paper describes the extension of a previously published method based on liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ESI-MS/MS) from 39 to currently 87 analytes. Besides the mycotoxins for which regulated concentrations exist, the method now comprises not only almost
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